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Journal of Clinical Psychiatry

22 Papers Indexed in Blossom

Published Papers

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Efficacy and Safety of a Single Dose of Psilocybin for Chronic Suicidal Ideation: An Open-Label Trial

This open-label single-arm trial (n=20) found that a single 25 mg dose of psilocybin with psychological support was linked to rapid and lasting reductions in chronic suicidal thoughts and depression over 12 weeks. No serious adverse events were reported.

Published
Journal
Journal of Clinical Psychiatry
Authors
Vaart, A. V. D., LaPratt, J., Swartz, K., Shoultz, A., Lauterbach, M., Suppes, T., Sackeim, H. A., Aaronson, S. T.
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Cognitive Behavioral Therapy Following Esketamine for Major Depression and Suicidal Ideation for Relapse Prevention: The CBT-ENDURE Randomized Trial

This randomised trial (n=93) found that adding 16 weeks of cognitive behavioural therapy to esketamine was feasible for people with major depression and suicidal ideation, and it reduced suicidal thoughts and depression scores more than esketamine with usual care alone. No difference was seen in suicide-related events.

Published
Journal
Journal of Clinical Psychiatry
Authors
Wilkinson, S. T., Kitay, B. M., Macaluso, M., Santucci, M. C., Kumpf, K., Voghell, C., Astorino, L., Hershenberg, R., Martinez-Kaigi, V., Nowell, T., Thase, M. E., Sanacora, G., Rhee, T. G.
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Results From a Long-Term Observational Follow-Up Study of a Single Dose of Psilocybin for a Treatment-Resistant Episode of Major Depressive Disorder

This one-year observational follow-up study (n=66) examined the long-term outcomes of psilocybin (25 mg, 10 mg, 1 mg; COMP360) in treatment-resistant depression (TRD). Median time to depressive relapse was longest in the 25 mg group (92 days) compared to 10 mg (83 days) and 1 mg (62 days), with most participants relapsing by week 12. A post hoc analysis of those entering the follow-up study (n=58) found a more pronounced difference, with the 25 mg group maintaining benefits for 189 days. Adverse events were minimal, with one case of mild suicidal ideation in the 1 mg group.

Published
Journal
Journal of Clinical Psychiatry
Authors
Goodwin, G. M., Nowakowska, A., Atli, M., Dunlop, B. W., Feifel, D., Hellerstein, D. J., Marwood, L., Shabir, Z., Mistry, S., Stansfield, S. C., Teoh, E., Tsai, J., Young, M. B., Malievskaia, E.
Open Accessindividual

Esketamine Nasal Spray vs Quetiapine Extended-Release: Examining Work Productivity Loss and Related Costs in Patients With Treatment-Resistant Depression

This secondary analysis (n=321) of the ESCAPE-TRD trial compared work productivity loss (WPL) and related costs in patients with treatment-resistant depression (TRD) receiving esketamine nasal spray (56mg or 84mg) versus quetiapine (atypical antipsychotic) extended release, both combined with an oral antidepressant. By week 8, WPL decreased by 30.3% with esketamine and 17.3% with quetiapine, leading to a cost savings difference of $156 per week. By week 32, WPL reductions were 45.3% (esketamine) and 32.5% (quetiapine), with a weekly cost savings difference of $153.

Published
Journal
Journal of Clinical Psychiatry
Authors
Clemens, K., Pmhnp-Bc, A., Teeple, D., Zhdanava, M., Shah, A., Joshi, K., Buyze, J., Pilon, D., Bowrey, H. E., Godinov, Y.
Paywallindividual

Barriers to Esketamine Nasal Spray Treatment Among Adults With Treatment-Resistant Depression

This retrospective observational cohort study (n=966 esketamine initiators, n=39,219 controls) examines factors influencing esketamine initiation and continuation for treatment-resistant depression (TRD). Initiators resided closer to treatment centres, with initiation rates decreasing significantly with distance. Factors associated with increased initiation included posttraumatic stress disorder, suicidal ideation, and male sex, while Medicaid, substance use disorder, older age, and greater distance were associated with lower initiation rates.

Published
Journal
Journal of Clinical Psychiatry
Authors
Joshi, K., Liberman, J. N., Parab, P., Darer, J. D., Harding, L.
Open Accessindividual

Microdosing psychedelics has no impact on cognitive function in naturalistic settings

In a within-subjects naturalistic study of 17 people repeatedly tested with the CNSVS battery, psychedelic microdosing produced no measurable improvement or impairment across processing speed, attention, executive function, working memory or memory. The authors suggest perceived benefits of microdosing are psychological rather than neurocognitive and note that remote cognitive batteries are feasible for longitudinal cross‑cultural research.

Published
Journal
Journal of Clinical Psychiatry
Authors
Dinkelacker, J., Pop, I.

Quick Facts

Papers Indexed
22
h-Index
236
Open Access
No
Publisher
Physicians Postgraduate Press
Country
United States
Website
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