Academic Journal

Neuroscience and Biobehavioral Reviews

22 Papers Indexed in Blossom

Published Papers

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Who Are You After Psychedelics? A Systematic Review and a Meta-Analysis of the Magnitude of Long-Term Effects of Serotonergic Psychedelics on Cognition/Creativity, Emotional Processing and Personality

This systematic review & meta-analysis (2024; s=10; n=304) synthesized data from contemporary studies, including both randomised and non-randomised controlled trials, to evaluate lasting effects of serotonergic psychedelics on cognition, creativity, emotional processing, and personality. Overall, no statistically significant effects were observed for most outcome measures; however, a meta-analysis of emotional recognition outcomes revealed faster reaction times in the active treatment groups for disgust and sadness.

Published
Journal
Neuroscience and Biobehavioral Reviews
Authors
Bayes, A., Brett, J., Haldane, K., Jayasena, T., Loo, C., Martin, D. M., Mason, N. L., Millard, M., Nikolin, S., Solaja, I., Weiss, B., Xu, M., Xu, X.
Open Accessmeta

Synthetic surprise as the foundation of the psychedelic experience

This hypothesis paper proposes that psychedelic agents like LSD and psilocybin induce altered states of consciousness by activating the 5-HT2A receptor system, leading to a state of synthetic surprise. This concept is based on recent understandings of serotonin's role in signaling surprise and is framed within the predictive coding framework, where surprise is seen as a mismatch between expectations and sensory input. The paper suggests that psychedelics disrupt maladaptive patterns by dynamically interacting with top-down expectations and sensory data, with implications for their clinical use, particularly emphasizing their ability to induce surprise to promote therapeutic effects.

Published
Journal
Neuroscience and Biobehavioral Reviews
Authors
De Filippo, R., Schmitz, D.
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Functional imaging studies of acute administration of classic psychedelics, ketamine, and MDMA: Methodological limitations and convergent results

This systematic review (s=51) examines fMRI studies on the acute effects of psychedelics like psilocybin, LSD, and ketamine on the human brain. The review highlights significant methodological inconsistencies across studies, including 54% not meeting contemporary Type I error correction or motion artefact control standards. Despite these limitations, convergent findings indicate that psilocybin and LSD affect the connectivity architecture of the sensorimotor-association cortical axis, while ketamine increases activation in the dorsomedial prefrontal cortex.

Published
Journal
Neuroscience and Biobehavioral Reviews
Authors
Basbaum, A., Corder, G., Dworkin, R. H., Edwards, R. R., Eickhoff, C. R., Larsen, I. B., Linguiti, S., McKinstry-Wu, A., Pines, A., Roalf, D. R., Satterthwaite, T. D., Scott, J. C., Sharma, V., Strain, E. C., Sydnor, V. J., Vogel, J. W., Wellman, N.

Quick Facts

Papers Indexed
22
h-Index
305
Open Access
No
Publisher
Elsevier
Country
United Kingdom
Website
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