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68 Papers Indexed in Blossom

Published Papers

Open Accessindividual

Mixed-methods analysis on psychedelic-augmented meditation experiences from a randomized controlled mindfulness retreat

This secondary analysis of a randomised controlled trial of DMT/harmine in experienced meditators found that meditation under DMT-harmine differed from placebo in its thematic and experiential profile while still sharing some semantic features. Using NLP-based analysis of phenomenological interviews, the study also suggested overlap between meditative and psychedelic states and highlighted the strong influence of context and spiritual framing on subjective experience.

Published
Journal
Scientific Reports
Authors
Schlomberg, J. T. T., Meling, D., Grylka, R., Vasella, E. A., Augustinovic, D., Scheidegger, M.
Open Accessindividual

Pilot study of psilocybin in patients with post-treatment lyme disease

In an open‑label, single‑arm pilot study of 20 patients with post‑treatment Lyme disease, two psilocybin sessions with psychological support produced significant, sustained reductions in symptom burden (40% decrease in GSQ‑30 at six months) and improvements in both physical and mental quality of life. The intervention was feasible and well-tolerated with no serious related adverse events, supporting further controlled trials of psilocybin‑assisted therapy for PTLD.

Published
Journal
Scientific Reports
Authors
Garcia-Romeu, A., Naudé, G. P., Rebman, A. W., So, S., Yaffe, A., Geithner, I., Kozero, E. A., Yang, T., Soloski, M. J., Aucott, J. N.
Open Accessindividual

Inhaled N, N-dimethyltryptamine diminishes connectivity between the ventral tegmental area and the nucleus accumbens: relevance to pathologies of mesolimbic and mesocortical pathways

In a within-subject pharmacoimaging study of 11 healthy psychedelic-experienced volunteers, inhaled DMT acutely reduced connectivity between the left ventral tegmental area and the right nucleus accumbens while increasing connectivity between the nucleus accumbens and anterior cingulate cortex and between the medial prefrontal cortex and anterior cingulate. These connectivity shifts correlated with changes in volition and perception and suggest a potential therapeutic mechanism for disorders of reward processing.

Published
Journal
Scientific Reports
Authors
Lima, G., Soares, C., Teixeira, M., Pais, M., Cabral, C., Rijo, P., Castelo-Branco, M.
Open Accessindividual

Acute experiences and persisting psychological effects associated with an encapsulated DMT-harmala alkaloid combination: results of a phase 1 study

This open-label study (n=9) found that an encapsulated DMT-harmala alkaloid product (pharmahuasca) produced dose-dependent mystical experiences that exceeded those reported in most previous ayahuasca studies and were associated with beneficial persisting psychological effects in healthy volunteers.

Published
Journal
Scientific Reports
Authors
Perkins, D., Halman, A., Urokohara, A., Palumbo, J., Low, M., Ruffell, S., Galvão-Coelho, N., Collins, L., Norman, A., Sarris, J.
Open Accessindividual

Mapping the phenomenology of intranasal 5-MeO-DMT in psychedelic-naïve healthy adults

This Phase I double-blind placebo-controlled trial (n=32) using microphenomenology interviews found that intranasal 5-MeO-DMT produced dose-dependent subjective effects with rapid onset peaking at 8-15 minutes and return to baseline by 45-60 minutes, characterised by minimal visual effects but strong emotional and bodily experiences, including emotional breakthroughs and personal insights.

Published
Journal
Scientific Reports
Authors
Ermakova, A. O., Dunbar, F., Seynaeve, M., Millière, R.
Open Accessindividual

Ayahuasca-assisted meaning reconstruction therapy as an early resource for bereavement: a non-randomized clinical trial

In this non-randomised, three-arm clinical trial of 84 adults bereaved within 12 months, ayahuasca-assisted meaning reconstruction therapy (A-MR) was well tolerated and produced significantly larger reductions in grief severity and greater improvements in prolonged grief symptoms, post‑traumatic growth and quality of life than meaning reconstruction alone or no treatment. These preliminary findings support A-MR as a potentially effective early intervention for severe grief but require replication in larger randomised trials.

Published
Journal
Scientific Reports
Authors
Soto-Angona, Ó., Andión, O., Sabucedo, P., Neimeyer, R. A., Haro, J. M., Javkin, J., Farré, M., González, D.

Quick Facts

Papers Indexed
68
h-Index
347
Open Access
Yes
Publisher
Oxford University Press
Country
United Kingdom
Website
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