Dynamic coupling of whole-brain neuronal and neurotransmitter systems
The authors present a multimodal neuroimaging framework demonstrating fundamental principles of bidirectional coupling between whole-brain neuronal dynamics and neurotransmitter systems, and use it to causally link 5‑HT2A receptor stimulation by psilocybin to observed functional brain effects in healthy humans. This approach offers a mechanistic basis for understanding how serotonergic modulation may underlie psilocybin’s therapeutic potential in neuropsychiatric disorders.
Authors
- Gitte Knudsen
- Robin Carhart-Harris
- Morten Kringelbach
Published
Abstract
Significance In a technical tour de force, we have created a framework demonstrating the underlying fundamental principles of bidirectional coupling of neuronal and neurotransmitter dynamical systems. Specifically, in the present study, we combined multimodal neuroimaging data to causally explain the functional effects of specific serotoninergic receptor (5-HT 2A R) stimulation with psilocybin in healthy humans. Longer term, this could provide a better understanding of why psilocybin is showing considerable promise as a therapeutic intervention for neuropsychiatric disorders including depression, anxiety, and addiction.
Research Summary of 'Dynamic coupling of whole-brain neuronal and neurotransmitter systems'
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Study Details
- Study Typeindividual
- Journal
- Compound
- Topics
- Authors
- APA Citation
Kringelbach, M. L., Cruzat, J., Cabral, J., Knudsen, G. M., Carhart-Harris, R., Whybrow, P. C., Logothetis, N. K., & Deco, G. (2020). Dynamic coupling of whole-brain neuronal and neurotransmitter systems. Proceedings of the National Academy of Sciences, 117(17), 9566-9576. https://doi.org/10.1073/pnas.1921475117
Cited By (20)
Papers in Blossom that reference this study
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Lyons, T., Spriggs, M. J., Kerkelä, L. et al. · Biorxiv (2024)
Vohryzek, J., Cabral, J., Lord, L. D. et al. · Brain Communications (2024)
Mallaroni, P., Mason, N. L., Kloft, L. et al. · Frontiers in Neuroscience (2023)
Vohryzek, J., Cabral, J., Timmermann, C. et al. · National Science Review (2023)
McCulloch, D. E-W., Olsen, A. S., Ozenne, B. et al. · MedRvix (2023)
Whelan, T. P., Daly, E., Puts, N. A. et al. · MedRvix (2023)
Show all 20 papersShow fewer
Herzog, R., Mediano, P. A. M., Rosas, F. E. et al. · Scientific Reports (2023)
Timmermann, C., Roseman, L., Haridas, S. et al. · PNAS (2023)
Olsen, A. S., Ozenne, B., Madsen, M. K. et al. · NeuroImage (2022)
Singleton, S. P., Luppi, A. I., Carhart-Harris, R. L. et al. · Nature Communications (2022)
Luppi, A. I., Hansen, J. Y., Adapa, R. et al. · Biorxiv (2022)
McCulloch, D. E-W., Knudsen, G. M., Barrett, F. S. et al. · Neuroscience and Biobehavioral Reviews (2022)
Burt, J. B., Preller, K. H., Demirtaş, M. et al. · eLife (2021)
Pallavicini, C., Cavanna, F., Zamberlan, F. et al. · Journal of Psychopharmacology (2021)
Luppi, A. I., Carhart-Harris, R. L., Roseman, L. et al. · NeuroImage (2021)
Nichols, D. E., Walter, H. · Pharmacopsychiatry (2020)
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