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Home/Research/5-MeO-DMT/Traumatic Brain Injury (TBI)

5-MeO-DMT for Traumatic Brain Injury (TBI)

1 paper and 1 clinical trial exploring 5-meo-dmt as a treatment for traumatic brain injury (tbi).

CompoundTryptamine

5-MeO-DMT

A potent tryptamine psychedelic known for profound mystical experiences, currently under clinical investigation for TRD and anxiety.

Full 5-MeO-DMT profile
IndicationApproximately 70 million individuals worldwide sustain a TBI each year.

Traumatic Brain Injury (TBI)

Psychedelics are being investigated for their potential therapeutic effects on Traumatic Brain Injury (TBI), a condition that frequently results in various physical and psychological impairments. Early preclinical studies suggest that these compounds may influence inflammatory responses, promote neuroplasticity, and enhance neurogenesis, offering new avenues for treatment.

Full Traumatic Brain Injury (TBI) profile

Academic Research

1 paper
Open Accessindividual

Prospective associations of psychedelic treatment for co-occurring alcohol misuse and posttraumatic stress symptoms among United States Special Operations Forces Veterans

This prospective study (n=86) evaluated the effects of ibogaine & 5-MeO-DMT treatment on risky alcohol use & PTSD symptoms among US Special Operations Forces Veterans. It found a significant reduction in alcohol use from pre-treatment to 1-month, 3-months, and 6-months post-treatment, and large differences between responders and non-responders in PTSD symptom and cognitive functioning change, suggesting that psychedelic-assisted therapy may hold promise for individuals with complex trauma and alcohol misuse.

Published
February 1, 2023
Journal
Military Medicine
Authors
Armstrong, S. B., Xin, Y., Sepeda, N. D., Polanco, M., Averill, L. A., Davis, A. K.

Clinical Trials

1 trial
WithdrawnPhase II

Trifecta Research Study

Non-randomised, parallel interventional study (n=40) testing sequences of HRT, MeRT, ibogaine and 5‑MeO‑DMT in Special Operations Forces veterans with PTSD and cognitive difficulties following TBI.

Started
March 1, 2025
Type
interventional
Blinding
none
Randomized
No
Registry ID
NCT06810765

Explore further

Search all 5-MeO-DMT papers Search all Traumatic Brain Injury (TBI) trials Full 5-MeO-DMT profile Full Traumatic Brain Injury (TBI) profile