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Home/Research/DMT/Alcohol Use Disorder (AUD)

DMT for Alcohol Use Disorder (AUD)

2 papers and 3 clinical trials exploring dmt as a treatment for alcohol use disorder (aud).

CompoundTryptamine

DMT

A powerful, short-acting tryptamine psychedelic found in many botanical sources, known for rapid onset and intense subjective experiences.

Full DMT profile
IndicationOver 100 million cases worldwide, making AUD the most common substance use disorder.

Alcohol Use Disorder (AUD)

Alcohol Use Disorder (AUD) is a prevalent condition characterised by an inability to control alcohol consumption despite adverse consequences. Emerging research indicates that psychedelics may offer promising therapeutic avenues for treating AUD, with various compounds showing potential in clinical trials.

Full Alcohol Use Disorder (AUD) profile

Academic Research

2 papers
Open Accessindividual

Psilocybin-assisted therapy for relapse prevention in alcohol use disorder: a phase 2 randomized clinical trial

This double-blind randomised clinical trial (n=37) found that a single dose of psilocybin (25mg) with brief psychotherapy did not significantly reduce alcohol relapse rates or consumption compared to placebo in patients with alcohol use disorder (AUD) at 4-week or 6-month follow-up, though psilocybin participants reported additional reductions in craving and temptation to drink, suggesting larger trials are needed to evaluate this approach for severely affected patients.

Published
April 1, 2025
Journal
EClinicalMedicine
Authors
Rieser, N. M., Bitar, R., Halm, S., Rossgoderer, C., Gubser, L. P., Thévenaz, M., Kreis, Y., Von Rotz, R., Nordt, C., Visentini, M., Moujaes, F., Engeli, E. J. E., Ort, A., Seifritz, E., Vollenweider, F. X., Herdener, M., Preller, K. H.
Open Accessmeta

The psychopharmacology of hallucinogens

This review paper (1996) examines the history and epidemiology of hallucinogens (LSD, Mescaline, MDM, MDMA, Psilocybin, Ibogaine, Harmine, and DMT) with respect to their psychotic effects, hallucinogen persisting perception disorder, and therapeutic efficacy. Representative studies include 13 publications on LSD therapy to treat alcoholism (n=1409), and 16 studies on post-LSD psychoses (n=75).

Published
April 1, 1996
Journal
Neuropsychopharmacology
Authors
Abraham, H. D., Aldridge, A. M., Gogia, P.

Clinical Trials

3 trials
RecruitingPhase I

The Potential Therapeutic Effects of Psychedelic, N, N-dimethyltryptamine (DMT), on Alcohol Use Disorder (AUD)

This double-blind, randomized, placebo-controlled, parallel-group laboratory trial (n=63) conducted by Yale University aims to determine the effects of DMT (14-21mg/70kg/min) infusions, in conjunction with psychotherapy, on Alcohol Use Disorder (AUD).

Started
March 17, 2024
Type
interventional
Blinding
double
Randomized
Yes
Registry ID
NCT06070649
Active not recruitingPhase NA

Understanding Neuroplasticity Induced by TrYptamines (UNITy): the effects of dimethyltryptamine (DMT) on drinking

Randomised, double-blind, placebo-controlled 2×2 factorial mechanistic study (n=120) testing 25 mg IV DMT vs placebo combined with alcohol memory reactivation in non-treatment-seeking hazardous/harmful drinkers.

Started
October 30, 2020
Type
interventional
Blinding
double
Randomized
Yes
Registry ID
ISRCTN13970288
CompletedPhase NA

DPT-Assisted Psychedelic-Peak Psychotherapy for Alcoholism: An Open Clinical Study (Grof 1973, Spring Grove State Hospital)

Exploratory, open clinical study (International Pharmacopsychiatry 1973; Grof S, Soskin RA, Richards WA, Kurland AA; Spring Grove State Hospital, Baltimore, MD, USA). Participants: 51 alcoholic patients drawn from the Alcoholic Rehabilitation Unit of Spring Grove State Hospital, selected by medical and psychiatric screening for suitability for psychedelic-peak therapy. Exclusions included organic brain damage, epilepsy, active renal or hepatic disease, and other specified contraindications. Intervention: dipropyltryptamine (DPT), a synthetic short-acting psychedelic, administered as an adjunct to psychotherapy in a psychedelic-peak therapy framework. No control arm; open-label exploratory design. Outcomes: clinical and psychotherapeutic change in alcoholism. No trial registry; pre-dates any formal registration requirement by ~32 years.

Started
January 1, 1970
Type
interventional
Randomized
No
Registry ID
GROF-1973-IPP-DPT-ALCOHOL-SPRING-GROVE

Explore further

Search all DMT papers Search all Alcohol Use Disorder (AUD) trials Full DMT profile Full Alcohol Use Disorder (AUD) profile