The Potential Therapeutic Effects of Psychedelic, N, N-dimethyltryptamine (DMT), on Alcohol Use Disorder (AUD)
This double-blind, randomized, placebo-controlled, parallel-group laboratory trial (n=63) conducted by Yale University aims to determine the effects of DMT (14-21mg/70kg/min) infusions, in conjunction with psychotherapy, on Alcohol Use Disorder (AUD).
Details
Randomized, double-blind, placebo-controlled parallel-group laboratory study evaluating single-session intravenous DMT infusions plus a short course of psychotherapy in individuals with Alcohol Use Disorder.
Three arms compare a high-rate DMT bolus (0.3 mg/kg/min, 5 min) with a low-rate bolus plus maintenance (0.2 mg/kg/min bolus then 0.01 mg/kg/min maintenance) and an active placebo (25 mg diphenhydramine bolus); outcomes include safety, tolerability, and laboratory-measured alcohol consumption up to 8 weeks.
Psychotherapy is provided alongside dosing; primary aims are safety, tolerability, and reduction in alcohol consumption compared with active placebo.