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Home/Research/Placebo/Equity and Ethics

Placebo for Equity and Ethics

1 paper and 1 clinical trial exploring placebo as a treatment for equity and ethics.

CompoundComparator / Control

Placebo

Placebo is the most widely referenced comparator in psychedelic clinical research, appearing in over 500 trials. Understanding how placebos are designed, administered, and interpreted is essential to evaluating the evidence base for psychedelic-assisted therapies — and one of the field’s most contested methodological challenges.

Full Placebo profile
IndicationApproximately 1 in 4 adults experience mental health disorders annually worldwide.

Equity and Ethics

Equity and ethics in psychedelic research is a vital and complex topic, addressing the need for fair access and representation in clinical trials, as well as the stewardship of traditional knowledge. The involvement of Indigenous communities, who have historically used these substances, must be safeguarded against exploitation as the field matures.

Full Equity and Ethics profile

Academic Research

1 paper
Open Accessindividual

Effects of external stimulation on psychedelic state neurodynamics

This further analysis of data from a single-blind, placebo-controlled study (n=20) on the effects of LSD (75µg) finds that the context (eyes closed/open, silence/music/video) modulates the level of brain entropy. The study finds that eyes-closed elicited the biggest response, and that video (external stimuli) disrupts the correlation between brain entropy and subjective ratings of the experience.

Published
January 12, 2024
Journal
ACS Chemical Neuroscience
Authors
Mediano, P. A. M., Rosas, F. E., Timmermann, C., Roseman, L., Nutt, D. J., Feilding, A., Kaelen, M., Kringelbach, M. L., Barrett, A. B., Seth, A. K., Muthukumaraswamy, S., Bor, D., Carhart-Harris, R. L.

Clinical Trials

1 trial
RecruitingPhase NA

Evaluating the atittudes of Australian psychologists, psychiatrists and mental health researchers towards 3,4-Methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for the treatment of PTSD: A double-blind, randomised controlled trial

This double-blind, randomised controlled trial (n=200) aims to evaluate the attitudes of Australian psychologists, psychiatrists, and mental health researchers towards MDMA-assisted psychotherapy for the treatment of PTSD.

Started
February 11, 2020
Type
interventional
Blinding
single
Randomized
Yes
Registry ID
ACTRN12620001068954

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