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Home/Research/Placebo/Health Economics & Reimbursement

Placebo for Health Economics & Reimbursement

2 papers and 2 clinical trials exploring placebo as a treatment for health economics & reimbursement.

CompoundComparator / Control

Placebo

Placebo is the most widely referenced comparator in psychedelic clinical research, appearing in over 500 trials. Understanding how placebos are designed, administered, and interpreted is essential to evaluating the evidence base for psychedelic-assisted therapies — and one of the field’s most contested methodological challenges.

Full Placebo profile
IndicationApproximately 300 million individuals worldwide suffer from depression, with PTSD affecting about 7-8% of the US population at some point in their lives.

Health Economics & Reimbursement

Psychedelic-assisted therapies are gaining traction in the health economics domain, with promising findings regarding their efficacy in treating mental health disorders. As the FDA considers approval for compounds like MDMA and psilocybin, the economic implications, including reimbursement models, are increasingly relevant to healthcare systems worldwide.

Full Health Economics & Reimbursement profile

Academic Research

2 papers
Paywallindividual

Safety, tolerability, pharmacokinetics, and subjective effects of 50, 75, and 100 µg LSD in healthy participants within a novel intervention paradigm: A proof-of-concept study

This trial (n=32) assessed the safety, tolerability, pharmacokinetics, and subjective effects of 50, 75, and 100 µg LSD in healthy adults within a novel intervention paradigm. Participants received 50 (n = 3), 75 (n = 7), 100 (n = 3) LSD, 50 µg followed by 75 µg LSD (n = 9) 1 week apart, or placebo followed by a 75 µg LSD (n = 10) 1 week apart. No serious adverse events were reported, This data indicates that LSD is safe and well-tolerated with mild adverse events reported.

Published
March 7, 2022
Journal
Journal of Psychopharmacology
Authors
Family, N., Hendricks, P. S., Williams, L. T. J., Luke, D., Krediet, E., Raz, S., Malliet, E. L.
Open Accessmeta

The cost-effectiveness of MDMA-assisted psychotherapy for the treatment of chronic, treatment-resistant PTSD

This study (2020) on the costs (and benefits) of MDMA-assisted therapy for PTSD finds it to be more cost-effective than other treatments. It's based on the data from six double-blind, placebo-controlled phase II trials (n=105) done by MAPS.

Published
October 14, 2020
Journal
PLOS ONE
Authors
Marseille, E., Kahn, J. G., Yazar-Klosinski, B., Doblin, R.

Clinical Trials

2 trials
RecruitingPhase II

LSD to Improve Cluster Headache Impact Trial

This double-blind, placebo-controlled trial (n=65) will assess the efficacy and safety of LSD (25μg) every 3 days for 3 weeks versus placebo in treating chronic cluster headaches (CCH).

Started
January 1, 2024
Type
interventional
Blinding
quadruple
Randomized
Yes
Registry ID
NCT05477459
Active not recruitingPhase III

A randomised controlled trial of oral S-ketamine as add-on medication for patients with treatment-resistant major depressive disorder

This double-blind, placebo-controlled parallel-group Phase III trial (n=128) evaluates oral S-ketamine capsules as add-on treatment over 6 weeks for patients with treatment-resistant major depressive disorder (TRD).

Started
August 29, 2016
Type
interventional
Blinding
double
Randomized
Yes
Registry ID
2015-003957-16

Explore further

Search all Placebo papers Search all Health Economics & Reimbursement trials Full Placebo profile Full Health Economics & Reimbursement profile