A randomised, double-blind, placebo-controlled trial to study the effects of repeated microdoses of lysergic acid diethylamide (LSD) on creativity and brain activity in healthy adult males
This randomized, double-blind, placebo-controlled trial (n=80) will study the effects of repeated microdoses of lysergic acid diethylamide (LSD) on creativity and brain activity in healthy adult males. Participants will receive either 10 µg of LSD or a placebo, dissolved in water in 1 ml oral syringes, taken once every three days for a total of 14 doses over a 41-day regimen.
Details
Randomised, double-blind, parallel-group study in healthy male volunteers (25–60 years) comparing repeated microdoses of LSD (10 µg) with matched placebo over 14 dosing sessions across 41 days.
Primary assessments include creative thinking (Alternate Uses Test) and EEG measures (mismatch negativity) at baseline, 2 hours after first administration (Day 1), and 2 days after the final administration (Day 43). Adherence is monitored via participant-recorded dosing videos; a titration amendment permits starting at 5 µg with +1 µg increments to a 10 µg maximum if poorly tolerated.