This observational cohort study (n=1756) aims to collect long-term outcomes from the RSI trial (NCT05277896). It was conducted by Vanderbilt University Medical Center and led by Jonathan Casey, MD, MSc.
The RSI-LTO study is a prospective cohort following critically ill adults enrolled in the RSI trial to measure long-term outcomes including PTSD symptoms after emergency tracheal intubation; the study compares groups assigned to ketamine versus etomidate during induction.
Recommended induction doses in the parent RSI trial were ketamine 2 mg/kg IV and etomidate 0.3 mg/kg IV (nomograms provided); clinicians may adjust dosing. Outcomes assess PTSD, mental health, function, and related sequelae over follow-up.
Intravenous ketamine as the sedative for induction of anesthesia during emergency tracheal intubation.
Recommended dose 2 mg/kg; nomogram provided; clinicians may adjust dose.
Intravenous etomidate as the sedative for induction of anesthesia during emergency tracheal intubation.
Etomidate 0.3 mg/kg recommended; nomogram provided; clinicians may adjust dose.