Effect of Ketamine and Etomidate During RSI on Long Term Outcomes (RSI-LTO)

The RSI-LTO study is a prospective cohort following critically ill adults enrolled in the RSI trial to measure long-term outcomes including PTSD symptoms after emergency tracheal intubation; the study compares groups assigned to ketamine versus etomidate during induction.

Recommended induction doses in the parent RSI trial were ketamine 2 mg/kg IV and etomidate 0.3 mg/kg IV (nomograms provided); clinicians may adjust dosing. Outcomes assess PTSD, mental health, function, and related sequelae over follow-up.