This study evaluates the effects of Salvinorin A (SA). SA is the active ingredient of the plant Salvia divinorum that is known to have been used by Mexican Indians as part of religious rituals. The purpose of this project is to understand what people experience when they consume Salvinorin A.
Randomised, crossover early-phase study in healthy volunteers testing inhaled Salvinorin A at multiple single-dose levels (250, 500, 750 µg) versus placebo for basic science outcomes.
Primary purpose listed as basic science; outcomes and measures focused on acute subjective and physiological responses. Actual enrolment reported as 105 participants.
Active Salvinorin A (three dose levels) in crossover design.
Low 250 µg; Medium 500 µg; High 750 µg; inhaled.
Placebo (30% ethanolic solution).
30% ethanolic solution as placebo.
No exclusion criteria listed.