Randomised, triple-blind, crossover early-phase study (n=43) comparing single oral MDMA 125 mg, methamphetamine 20 mg, and placebo in healthy volunteers to assess social motivation, social ability, and neural indices of social function.
Randomised, triple-blind, three-period crossover in healthy volunteers comparing single oral doses of MDMA (125 mg), methamphetamine (20 mg), and placebo with 5 days between sessions; primary purpose basic science.
Outcomes assess behavioural measures of social motivation and ability and neural indices of social function; enrolment reported as 43 actual participants.
Three-period crossover: placebo, MDMA 125 mg, and methamphetamine 20 mg (single doses; order randomised).
Single oral 125 mg MDMA; one session per condition, 5 days between sessions.
Single oral 20 mg methamphetamine (MA).
Placebo oral tablet containing lactose.