This study is designed to investigate whether low-dose s-ketamine administered after childbirth can reduce the incidence of postpartum depression in parturients with prenatal depression.
Randomized, parallel-group prevention trial in parturients with prenatal depression testing a single post‑delivery IV infusion of low‑dose S‑ketamine (0.2 mg/kg) versus saline placebo.
Primary aim is reduction in incidence of postpartum depression; participants receive infusion after childbirth and are monitored for safety (60 minutes) with follow-up assessments for depressive symptoms.
Single IV infusion of low-dose S-ketamine (postpartum) with 60 min monitoring.
0.2 mg/kg in 20 ml normal saline infused over 40 minutes; monitored 60 minutes post-infusion.
Single IV infusion of normal saline with 60 min monitoring.
20 ml normal saline infused over 40 minutes; monitored 60 minutes post-infusion.