Low-dose S-Ketamine and Postpartum Depression in Parturients With Prenatal Depression

Randomized, parallel-group prevention trial in parturients with prenatal depression testing a single post‑delivery IV infusion of low‑dose S‑ketamine (0.2 mg/kg) versus saline placebo.

Primary aim is reduction in incidence of postpartum depression; participants receive infusion after childbirth and are monitored for safety (60 minutes) with follow-up assessments for depressive symptoms.