Low-dose S-ketamine in Women With Prenatal Depression

This parallel, randomised, quadruple-blind study will compare a single postnatal infusion of S-ketamine (0.2 mg/kg) with placebo in women who screened positive for prenatal depression to assess incidence of postpartum depression.

The active infusion is delivered in 20 ml saline at 30 ml/h (40 minutes) with 60 minutes of monitoring; primary purpose is prevention, with outcomes including postpartum depression incidence and safety/tolerability.