Randomised, parallel-group prevention trial (n=364) testing a single low-dose S-ketamine infusion (0.2 mg/kg IV) after childbirth to reduce postpartum depression in women with prenatal depression.
This parallel, randomised, quadruple-blind study will compare a single postnatal infusion of S-ketamine (0.2 mg/kg) with placebo in women who screened positive for prenatal depression to assess incidence of postpartum depression.
The active infusion is delivered in 20 ml saline at 30 ml/h (40 minutes) with 60 minutes of monitoring; primary purpose is prevention, with outcomes including postpartum depression incidence and safety/tolerability.
Single intravenous infusion of S-ketamine 0.2 mg/kg after childbirth; monitored post-infusion.
0.2 mg/kg in 20 ml saline infused at 30 ml/h (40 minutes); monitored 60 minutes post-infusion.
Single intravenous infusion of normal saline after childbirth; monitored post-infusion.
20 ml normal saline infused at 30 ml/h (40 minutes); monitored 60 minutes post-infusion.