PAPR: PAP + MBSR for Front-line Healthcare Provider COVID-19 Related Burnout (PAPR)
Open-label, randomised, parallel two-arm Phase I study (n=24) comparing 8-week MBSR vs 8-week MBSR plus a single 25 mg psilocybin-assisted group psychotherapy session for frontline healthcare providers with depression and burnout.
Details
Randomised, open-label, parallel-group design allocating 24 frontline physicians or nurses to 8-week MBSR alone or MBSR plus psilocybin-assisted psychotherapy (PAP). Primary aim is to treat depressive symptoms and burnout related to COVID-19 frontline work.
The PAP intervention comprises three 2-hour preparatory group sessions, a single 8-hour group psilocybin administration session (25 mg oral, 1:1 therapist-to-participant ratio), and three 2-hour group integration sessions; outcomes include mood, burnout measures, and safety/tolerability.