Psilocybin for the Treatment of Cluster Headache

Randomised, triple-masked crossover study in participants with cluster headache comparing three-session pulse regimens of high-dose, low-dose and placebo psilocybin; sessions occur approximately 5 days apart.

Participants maintain a headache diary before, during and after the pulse regimen to document frequency and intensity; participants may be invited for a second round after at least six months and will be randomised to low or high dose.