THC and Ketamine Effects in Humans: Relation to Neural Oscillations and Psychosis

Healthy volunteers receive IV Delta-9-THC (0.015 mg/kg) and IV ketamine (0.2 mg/kg) in a double-blind, randomized 2×2 crossover; each session pairs THC (active or placebo) followed by ketamine (active or placebo).

Primary outcomes include EEG measures of neural oscillations during peak drug effects and psychotomimetic/cognitive assessments to probe CB1R and NMDAR contributions to psychosis-like phenomena.