| 2025 | US Advanced Research Projects Agency for Health (ARPA-H) | Diamond Therapeutics | $2,000,000 | ARPA-H EVIDENT — Psilocybin for generalized anxiety disorder (Phase 2a data) | Psilocybin | Anxiety Disorders | Source ↗ |
| 2025 | US Advanced Research Projects Agency for Health (ARPA-H) | Duke University | $2,000,000 | ARPA-H EVIDENT — Stress physiology biomarkers for behavioral health | — | — | Source ↗ |
| 2025 | Congressionally Directed Medical Research Programs | Emory University | $4,900,000 | DoD — MDMA-assisted therapy + massed prolonged exposure for active-duty PTSD | MDMA | PTSD | Source ↗ |
| 2025–2028 | National Institute on Alcohol Abuse and Alcoholism (NIAAA) | Psilera | $2,000,000 | NIAAA SBIR — Novel neuroplastogen for alcohol use disorder | — | Alcohol Use Disorder (AUD) | Source ↗ |
| 2025 | US Advanced Research Projects Agency for Health (ARPA-H) | University of Wisconsin-Madison | $2,000,000 | ARPA-H EVIDENT — Conscious vs non-conscious mechanisms of psilocybin therapy | Psilocybin | — | Source ↗ |
| 2025 | Congressionally Directed Medical Research Programs | Walter Reed National Military Medical Center | $4,900,000 | DoD — MDMA-assisted therapy for active-duty PTSD (Walter Reed cohort) | MDMA | PTSD | Source ↗ |
| 2025 | National Institute on Drug Abuse (NIDA) | atai Life Sciences | $11,400,000 | NIDA UG3/UH3 — Non-hallucinogenic 5-HT2A/2C agonists for opioid use disorder | — | Opioid Use Disorder (OUD) | Source ↗ |
| 2024 | National Institute on Drug Abuse (NIDA) | Gilgamesh Pharma | $14,000,000 | NIDA — GM-3009 ibogaine analog for opioid use disorder | Ibogaine | Opioid Use Disorder (OUD) | Source ↗ |
| 2024–2029 | National Institute on Drug Abuse (NIDA) | NYU Center for Psychedelic Medicine | $15,000,000 | NIDA — Psilocybin for opioid use disorder (landmark $15M trial) | Psilocybin | Opioid Use Disorder (OUD) | Source ↗ |
| 2024 | National Institute on Alcohol Abuse and Alcoholism (NIAAA) | NYU Center for Psychedelic Medicine | $3,800,000 | NIAAA — Psilocybin for alcohol use disorder (Phase 2 fMRI mechanistic trial) | Psilocybin | Alcohol Use Disorder (AUD) | Source ↗ |
| 2024–2028 | European Commission (Horizon Europe) | University Medical Center Groningen | €6,500,000 | Horizon Europe — PsyPal: psilocybin therapy in palliative care | Psilocybin | Palliative & End-of-Life Distress | Source ↗ |
| 2024–2029 | National Institute on Drug Abuse (NIDA) | University of California San Diego | $2,400,000 | NIDA — Non-classic psychedelics for methamphetamine use disorder | — | Substance Use Disorders (SUD) | Source ↗ |
| 2024–2029 | U.S. Department of Veterans Affairs (VA) | Yale University | $1,500,000 | VA — MDMA-assisted therapy for PTSD + alcohol use disorder in veterans | MDMA | PTSD | Source ↗ |
| 2023–2027 | National Center for Complementary and Integrative Health (NCCIH) | Johns Hopkins Center for Psychedelic and Consciousness Research | $1,518,560 | NCCIH R33AT012317 — Psilocybin and affective function in chronic low-back pain + depression | Psilocybin | Chronic Pain | Source ↗ |
| 2022–2027 | Medical Research Future Fund (MRFF) | Monash University | A$2,700,000 | MRFF — Psilocybin-assisted psychotherapy for treatment-resistant depression | Psilocybin | Treatment-Resistant Depression (TRD) | Source ↗ |
| 2022–2027 | National Cancer Institute (NCI) | NYU Center for Psychedelic Medicine | $2,627,155 | NCI R01CA268521 — Psilocybin for cancer-related psychiatric and existential distress | Psilocybin | Palliative & End-of-Life Distress | Source ↗ |
| 2022–2027 | Medical Research Future Fund (MRFF) | University of Sydney | A$1,900,000 | MRFF — MDMA-assisted treatment for PTSD + alcohol use disorder | MDMA | PTSD | Source ↗ |
| 2021–2024 | National Institute on Drug Abuse (NIDA) | Johns Hopkins Center for Psychedelic and Consciousness Research | $4,000,000 | NIDA U01DA052174 — Multisite psilocybin trial for smoking cessation | Psilocybin | Tobacco/Nicotine Use Disorder (TUD) | Source ↗ |
| 2021 | National Institute of Mental Health (NIMH) | Yale University | $800,000 | NIMH K-award — Psilocybin for treatment-resistant OCD (Kelmendi) | Psilocybin | Obsessive-Compulsive Disorder (OCD) | Source ↗ |
| 2017–2022 | National Institute on Drug Abuse (NIDA) | Johns Hopkins Center for Psychedelic and Consciousness Research | $3,960,000 | NIDA R01 DA042103 — Psilocybin facilitation of smoking cessation | Psilocybin | Tobacco/Nicotine Use Disorder (TUD) | Source ↗ |
| 2014–2017 | Medical Research Council | Imperial College London | Amount undisclosed | MRC — Psilocybin for treatment-resistant depression (feasibility trial) | Psilocybin | Treatment-Resistant Depression (TRD) | Source ↗ |