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Academic Journal

European Neuropsychopharmacology

31 Papers Indexed in Blossom

Published Papers

Open Accessindividual

Long-term treatment with esketamine nasal spray in patients with treatment resistant depression: Results from the ESCAPE-LTE study

This Phase IV single-arm long-term extension trial (n=183) found that the vast majority of patients with treatment-resistant depression who achieved remission with esketamine nasal spray (plus an antidepressant) did not relapse over 136 weeks of treatment, with side effects largely resolving the same day and no new safety concerns identified.

Published
Journal
European Neuropsychopharmacology
Authors
Reif, A., Anıl, Y. A., Bitter, I., Buyze, J., Frey, R., Godinov, Y., Haggström, L., Kambarov, Y., Nielsen, R., Oliveira-Maia, A., von Holt, C., Cubała, W., DJ, F., AH, Y.
Open Accessmeta

Psychedelics: The pathway to implementation in the European healthcare systems

This review (2025) examines the challenges of integrating psychedelic therapies into European healthcare systems, highlighting that beyond obtaining regulatory approval, these treatments must also pass health technology assessments in individual countries, a process complicated by the lack of studies comparing psychedelics to existing treatments and the difficulty of evaluating therapies that combine drugs with psychotherapy.

Published
Journal
European Neuropsychopharmacology
Authors
Gründer, G., Mertens, L. J., Spangemacher, M., Meyer-Lindenberg, A., Jungaberle, H.
Paywallindividual

The effects of psilocybin therapy versus escitalopram on cognitive bias: A secondary analysis of a randomized controlled trial

This secondary analysis of an RCT comparing psilocybin therapy to escitalopram in MDD patients (n=59) found that psilocybin produced superior improvements in cognitive biases. Psilocybin significantly increased self-reported optimism (d=1.1) and optimistic beliefs about desirable life events (d=1.1), while improving all three domains of dysfunctional attitudes (achievement, dependency, and self-control). Escitalopram showed more modest effects, reducing pessimism about negative events and improving only the achievement domain of dysfunctional attitudes.

Published
Journal
European Neuropsychopharmacology
Authors
Henry, J., Giribaldi, B., Nutt, D. J., Erritzoe, D., Carhart-Harris, R., Lyons, T.
Paywallindividual

Safety, tolerability and subjective effects of vaporized N,N-Dimethyltryptamine: A randomized double-blind clinical trial

This first RCT (n=25) of vaporised DMT (60mg) demonstrated that DMT significantly increased subjective experience measures while causing only transient, safe physiological changes and predominantly mild adverse events. This suggests that inhaled DMT is safe, well-tolerated, and effective at inducing profound altered states of consciousness. Significant correlations were observed between physiological responses and subjective experiences.

Published
Journal
European Neuropsychopharmacology
Authors
Wießner, I., Falchi-Carvalho, M., Laborde, S., Barros, H., Bolcont, R., Ruschi Silva, S., Pantrigo, E. J., Medina, M., Arichelle, F., Almeida, R., Aires, R., Nunes Ferreira, L. F., Dantas Correa, L., da Costa Bezerra, R. B., Thie, K., Silva-Costa, N., Araújo, D. B., de Araujo Costa Neto, L. A., Lima de Queiroz, M. V. J., Galvão-Coelho, N. L., Palhano-Fontes, F.
Paywallmeta

Do classic psychedelics increase the risk of seizures? A scoping review

This scoping review (s=27) assesses the relationship between classic psychedelics and seizures. It finds that psychedelics may not increase seizure risk in healthy individuals or animals without other drugs, but concomitant use of substances like kambo or lithium could heighten the risk.

Published
Journal
European Neuropsychopharmacology
Authors
Soto-Angona, Ó., Fortea, A., Fortea, L., Martínez-Ramírez, M., Santamarina, E., López, F. J. G., Knudsen, G. M., Ona, G.
Open Accessindividual

Chemical cousins with contrasting behavioural profiles: MDMA users and methamphetamine users differ in social-cognitive functions and aggression

This comparative study (n=165) evaluated social cognitive functions and behaviors in chronic METH users, chronic MDMA users, and stimulant-naïve controls. METH users exhibited diminished cognitive and emotional empathy towards positive stimuli, elevated punitive social behavior regardless of provocation, and heightened trait anger. MDMA users showed a distinct rise in punitive behavior when provoked, with correlations suggesting associations between substance use patterns and social-cognitive deficits.

Published
Journal
European Neuropsychopharmacology
Authors
Zacher, A., Zimmermann, J., Cole, D. M., Friedli, N., Opitz, A., Baumgartner, M. R., Steuer, A. E., Verdejo-Garcia, A., Stock, A. K., Beste, C., Quednow, B. B.

Quick Facts

Papers Indexed
31
h-Index
136
Open Access
No
Publisher
Elsevier
Country
Netherlands
Website
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