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JAMA Network Open

9 Papers Indexed in Blossom

Published Papers

Open Accessindividual

Psilocybin or Nicotine Patch for Smoking Cessation A Pilot Randomized Clinical Trial

This pilot randomised clinical trial (n=82) found that a single dose of psilocybin (30mg/70kg) combined with cognitive behavioural therapy produced significantly higher long-term smoking abstinence rates at 6 months compared to nicotine patches plus CBT (41% vs 10%), with no serious adverse events attributed to either treatment.

Published
Journal
JAMA Network Open
Authors
Johnson, M. W., Naudé, G. P., Hendricks, P. S., Garcia-Romeu, A.
Open Accessmeta

Control Group Outcomes in Trials of Psilocybin, SSRIs, or Esketamine for Depression: A Meta-Analysis

This meta-analysis of 17 trials found that control-group participants in psilocybin depression trials showed markedly smaller improvements (SMC ≈ 0.50) on the MADRS than control participants in SSRI (SMC ≈ 1.00) or esketamine (SMC ≈ 1.12) trials. The authors conclude this disparity may indicate that psilocybin’s antidepressant efficacy is overestimated relative to SSRIs and esketamine, possibly because of functional unblinding and expectancy effects.

Published
Journal
JAMA Network Open
Authors
Hieronymus, F., López, E., Sjögren, H. W., Lundberg, J.
Open Accessindividual

Negative Affect Circuit Subtypes and Neural, Behavioral, and Affective Responses to MDMA: A Randomized Clinical Trial

In a double‑blind, placebo‑controlled within‑participant randomised trial of 16 adults stratified by baseline nonconscious‑threat–evoked amygdala activity, 120 mg MDMA acutely reduced amygdala and subgenual ACC activity, increased sgACC–amygdala connectivity, and raised likability of threat expressions in the high‑reactivity subgroup (NTNA+) versus the low‑reactivity subgroup. These results indicate that baseline neuroimaging of negative affect circuitry can identify biomarkers to personalise MDMA‑based therapies.

Published
Journal
JAMA Network Open
Authors
Zhang, X., Hack, L. M., Bertrand, C., Hilton, R., Gray, N. J., Boyar, L., Laudie, J., Heifets, B. D., Suppes, T., Van Roessel, P. J., Rodriguez, C. I., Deisseroth, K., Knutson, B., Williams, L. M.
Open Accessindividual

Psilocybin Therapy for Clinicians With Symptoms of Depression From Frontline Care During the COVID-19 Pandemic

In a double‑blind randomised clinical trial of 30 US frontline clinicians with pandemic‑related depression, a single 25 mg psilocybin session (with preparatory and integration visits) produced a significantly greater reduction in clinician‑rated depressive symptoms at 28 days than 100 mg niacin (mean MADRS change −21.33 vs −9.33; mean difference −12.00, 95% CI −17.67 to −6.33; P < .001). Improvements in burnout and PTSD symptoms were numerically larger with psilocybin but did not reach statistical significance.

Published
Journal
JAMA Network Open
Authors
Back, A., Freeman-Young, T. K., Morgan, L., Sethi, T., Baker, K. K., Myers, S., McGregor, B., Harvey, K., Tai, M., Kollefrath, A., Thomas, B. J., Sorta, D., Kaelen, M., Kelmendi, B., Gooley, T. A.
Open Accessindividual

Oxytocin and the Role of Fluid Restriction in MDMA-Induced Hyponatremia: A Secondary Analysis of 4 Randomized Clinical Trials

Pooled analysis of 96 participants in four randomised trials found that a single dose of MDMA produced acute hyponatraemia in about 31% (37% with unrestricted fluids) while no cases occurred with fluid restriction, indicating fluid management can mitigate risk. Hyponatraemia correlated with large acute rises in oxytocin but not copeptin, suggesting oxytocin‑mediated renal antidiuresis rather than direct vasopressin release.

Published
Journal
JAMA Network Open
Authors
Atila, C., Straumann, I., Vizeli, P., Beck, J., Holze, F., Liechti, M. E., Christ-Crain, M.
Open Accessindividual

Interrupting the Psychedelic Experience Through Contextual Manipulation to Study Experience Efficacy

This secondary analysis from a DMT study explores the impact of intentional cognitive interruptions on psychedelic experiences. The study investigates whether increasing cognitive load during the experience affects subjective ratings, hypothesizing that higher task demands would lower these ratings. Additionally, it examines whether reduced task demands correlate with larger reductions in long-term depressive symptoms.

Published
Journal
JAMA Network Open
Authors
Roseman, L., Erritzoe, D., Nutt, D. J., Carhart-Harris, R. L., Timmermann, C.

Quick Facts

Papers Indexed
9
h-Index
154
Open Access
Yes
Publisher
American Medical Association
Country
United States
Website
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