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Journal of Cognitive Neuroscience

3 Papers Indexed in Blossom

Published Papers

Open Accessindividual

Time-resolved Neural and Experience Dynamics of Medium- and High-dose N,N-Dimethyltryptamine

This repeated-measures dose-dependent study (n=19) investigates DMT's subjective and neural dynamics under naturalistic conditions. Participants received 20mg or 40mg doses of freebase DMT in a blinded, counterbalanced design, with EEG data and time-resolved subjective measures collected. The 40mg dose produced more intense visual hallucinations and emotional responses. Neural analyses revealed alpha power and permutation entropy were most associated with subjective experiences, whereas lempel-ziv complexity was less predictive, challenging prior assumptions about its role in psychedelic states.

Published
Journal
Journal of Cognitive Neuroscience
Authors
Lewis-Healey, E., Pallavicini, C., Cavanna, F., D'Amelio, T., de la Fuente, L. A., Copa, D., Muller, S., Bruno, N., Tagliazucchi, E., Bekinschtein, T.
Paywallindividual

Altered State of Consciousness and Mental Imagery as a Function of N, N-dimethyltryptamine Concentration in Ritualistic Ayahuasca Users

In ritualistic Santo Daime users, ayahuasca produced pronounced alterations in consciousness—especially oceanic boundlessness, visual restructuralization and ego dissolution—that correlated with peak serum DMT concentrations. Standard measures of mental imagery were largely unchanged (though perspective shifts and cognitive flexibility correlated with DMT), and peak alkaloid levels did not track dose, suggesting DMT primarily drives the acute phenomenology while long‑term use may attenuate imagery effects.

Published
Journal
Journal of Cognitive Neuroscience
Authors
Ramaekers, J. G., Mallaroni, P., Kloft, L., Reckweg, J., Toennes, S. W., van Oorsouw, K., Mason, N. L.
Open Accessindividual

Using Psilocybin to Investigate the Relationship between Attention, Working Memory, and the Serotonin 1A and 2A Receptors

This study tested the effects of psilocybin (15mg/70kg) on attentional tracking and spatial working memory, using a placebo-controlled design and ketanserin pretreatment condition to control for the 5-HT2A specific effects. Results indicated reduced attentional tracking ability, but unimpaired working memory, which was not related to 5-HT2A activity.

Published
Journal
Journal of Cognitive Neuroscience
Authors
Carter, O., Burr, D. C., Pettigrew, J. D., Wallis, G. M., Vollenweider, F. X.

Quick Facts

Papers Indexed
3
h-Index
244
Open Access
Yes
Publisher
MIT Press
Country
United States
Website
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