This repeated-measures dose-dependent study (n=19) investigates DMT's subjective and neural dynamics under naturalistic conditions. Participants received 20mg or 40mg doses of freebase DMT in a blinded, counterbalanced design, with EEG data and time-resolved subjective measures collected. The 40mg dose produced more intense visual hallucinations and emotional responses. Neural analyses revealed alpha power and permutation entropy were most associated with subjective experiences, whereas lempel-ziv complexity was less predictive, challenging prior assumptions about its role in psychedelic states.
- Published
- Journal
- Journal of Cognitive Neuroscience
- Authors
- Lewis-Healey, E., Pallavicini, C., Cavanna, F., D'Amelio, T., de la Fuente, L. A., Copa, D., Muller, S., Bruno, N., Tagliazucchi, E., Bekinschtein, T.