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Academic Journal

Pharmacological Reviews

5 Papers Indexed in Blossom

Published Papers

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Self-Entropic Broadening Theory: Toward a New Understanding of Self and Behavior Change Informed by Psychedelics and Psychosis

This review (2022) provides a theory of how changes due to (classical) psychedelics and psychosis have such different (positive vs negative) outcomes. This is done through the lens of self-entropic broadening theory (broader attentional scope, hyperassociative thinking), where psychedelics lead to low self-focus (awe, ego dissolution, mystical experiences), whilst psychosis leads to high self-focus (hyperreflexivity, self-referential processing).

Published
Journal
Pharmacological Reviews
Authors
Dourron, H. M., Strauss, C., Hendricks, P. S.
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Neural Mechanisms and Psychology of Psychedelic Ego Dissolution

This review (2022) investigates the neural mechanisms, 5HT2A receptor agonism at the top of the cortical hierarchy, that lead to ego dissolution and long-term neural plasticity. This study uses the hierarchical predictive coding framework to understand the neural mechanisms of consciousness (and psychedelics to test the model).

Published
Journal
Pharmacological Reviews
Authors
Stoliker, D., Egan, G. F., Friston, K. J., Razi, A.
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Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms

This review (2021) presents the neurobiological therapeutic mechanisms by which psychedelics work, with a focus on outcomes on 1) neuroplasticity, 2) immune system, and 3) effects on neurotransmitter (-modulator) systems.

Published
Journal
Pharmacological Reviews
Authors
Inserra, A., De Gregorio, D., Gobbi, G.
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REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics

This theoretical paper (2019) introduces the ‘REBUS’ (Relaxed Beliefs Under Psychedelics) model, integrating the free-energy principle with the entropic brain hypothesis. It proposes that psychedelics relax the precision weighting of high-level beliefs (priors), thereby liberating bottom-up information flow and enabling the revision of pathological or rigid thought patterns.

Published
Journal
Pharmacological Reviews
Authors
Carhart-Harris, R. L., Friston, K. J.
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Psychedelics

This paper is the most comprehensive review of psychedelics research up to 2016 by the eminent David E. Nichols.

Published
Journal
Pharmacological Reviews
Authors
Nichols, D. E.

Quick Facts

Papers Indexed
5
h-Index
264
Open Access
No
Publisher
American Society for Pharmacology and Experimental Therapeutics
Country
United States
Website
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