The effect of acutely administered MDMA on subjective and BOLD-fMRI responses to favourite and worst autobiographical memories
This double-blind, placebo-controlled, within-subjects fMRI study (n=19) investigated the effect of MDMA on the recollection of favorite and worst autobiographical memories (AMs). Positive memories were rated as more positive and negative memories as less negative after MDMA use. Several brain regions were found to be active during AM recollection and related to memory valance.
Authors
- Bloomfield, M.
- Bolstridge, M.
- Carhart-Harris, R. L.
Published
Abstract
3,4-methylenedioxymethamphetamine (MDMA) is a potent monoamine-releaser that is widely used as a recreational drug. Preliminary work has supported the potential of MDMA in psychotherapy for post-traumatic stress disorder (PTSD). The neurobiological mechanisms underlying its putative efficacy are, however, poorly understood. Psychotherapy for PTSD usually requires that patients revisit traumatic memories, and it has been argued that this is easier to do under MDMA. Functional magnetic resonance imaging (fMRI) was used to investigate the effect of MDMA on the recollection of favourite and worst autobiographical memories (AMs). Nineteen participants (five females) with previous experience with MDMA performed a blocked AM recollection (AMR) paradigm after ingestion of 100 mg of MDMA-HCl or ascorbic acid (placebo) in a double-blind, repeated-measures design. Memory cues describing participants' AMs were read by them in the scanner. Favourite memories were rated as significantly more vivid, emotionally intense and positive after MDMA than placebo and worst memories were rated as less negative. Functional MRI data from 17 participants showed robust activations to AMs in regions known to be involved in AMR. There was also a significant effect of memory valence: hippocampal regions showed preferential activations to favourite memories and executive regions to worst memories. MDMA augmented activations to favourite memories in the bilateral fusiform gyrus and somatosensory cortex and attenuated activations to worst memories in the left anterior temporal cortex. These findings are consistent with a positive emotional-bias likely mediated by MDMA's pro-monoaminergic pharmacology.
Research Summary of 'The effect of acutely administered MDMA on subjective and BOLD-fMRI responses to favourite and worst autobiographical memories'
Study Details
- Study Typeindividual
- Populationhumans
- Characteristicsdouble blindplacebo controlledcrossoverbrain measures
- Journal
- Compounds
- Topic
Cited By (34)
Papers in Blossom that reference this study
Ashraf, I., Azizi, L., Carhart-Harris, R. L. et al. · Biorxiv (2025)
Carhart-Harris, R. L., Castro-Rodrigues, P., Erritzoe, D. et al. · Nature Mental Health (2024)
Baggot, M. J., Baker, L. E., Baumann, M. H. et al. · Journal of Pharmacology and Experimental Therapeutics (2024)
Bedrosian, L., Cooker, A., Doblin, R. et al. · PLOS ONE (2024)
Erritzoe, D., Harding, R., Nutt, D. J. et al. · Molecular Psychiatry (2023)
Kuypers, K. P. C., Kvamme, T. L., Sarmanlu, M. et al. · Progress in Neuro-Psychopharmacology and Biological Psychiatry (2023)
Kangaslampi, S., Zijlmans, J. · European Child and Adolescent Psychiatry (2023)
Choi-Kain, L., Roberts, D. E., Ross, S. et al. · Focus (2022)
Coker, A., Doblin, R., Emerson, A. et al. · Frontiers in Psychiatry (2022)
Barrett, F. S., de Wit, H., Doss, M. K. et al. · Biorxiv (2022)
Show all 34 papersShow fewer
Bird, C. I. V., Modlin, N. L., Rucker, J. · International Review of Psychiatry (2021)
Bershad, A. K., de Wit, H., Grob, C. S. · Journal of Psychopharmacology (2021)
Brew-Girard, E., Burrows, S., Durant, C. et al. · Journal of Psychopharmacology (2021)
Andries, J., Carlin, S. C., Doblin, R. et al. · Scientific Reports (2020)
Brouwer, A., Carhart-Harris, R. L. · Journal of Psychopharmacology (2020)
Doblin, R., Emerson, A., Feduccia, A. A. et al. · Psychopharmacology (2020)
Feduccia, A. A., Garel, N., Greenway, K. T. et al. · Expert Review of Clinical Pharmacology (2020)
Doblin, R., Emerson, A., Feduccia, A. A. et al. · Frontiers in Psychiatry (2019)
Nutt, D. J. · Dialogues in Clinical Neuroscience (2019)
Doblin, R., Emerson, A., Feduccia, A. A. et al. · Journal of Psychopharmacology (2018)
Danforth, A. L., Emerson, A., Feduccia, A. A. et al. · Psychopharmacology (2018)
Andrews, A. M., Dunlap, L. E. · ACS Chemical Neuroscience (2018)
Schenberg, E. E. · Frontiers in Pharmacology (2018)
Feduccia, A. A., Mithoefer, M. C. · Progress in Neuro-Psychopharmacology and Biological Psychiatry (2018)
Farré, M., Muga, R., Papaseit, E. et al. · Expert Opinion on Drug Metabolism and Toxicology (2018)
Carhart-Harris, R. L., Nutt, D. J. · Journal of Psychopharmacology (2017)
de Wit, H., Doss, M. K., Gallo, D. A. et al. · Neuropsychopharmacology (2017)
de la Torre, R., Farré, M., Kuypers, K. P. C. et al. · Psychopharmacology (2017)
Doblin, R., Jerome, L., MacAulay, R. K. et al. · Journal of Psychopharmacology (2017)
Liechti, M. E., Vizeli, P. · Journal of Psychopharmacology (2017)
Baggot, M. J., Bershad, A. K., de Wit, H. et al. · Journal of Psychopharmacology (2016)
Sessa, B. · Neuroscience Letters (2016)
Amoroso, T., Workman, M. · Journal of Psychopharmacology (2016)
Baggot, M. J., Coyle, J. R., Galloway, G. P. et al. · Journal of Psychopharmacology (2015)