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Home/Research/MDMA/Equity and Ethics

MDMA for Equity and Ethics

18 papers and 1 clinical trial exploring mdma as a treatment for equity and ethics.

Compoundempathogen

MDMA

MDMA is a synthetic empathogen that enhances monoamine release, producing prosocial and anxiolytic effects without frank hallucinosis. Two Phase III trials demonstrated significant PTSD symptom reductions, though FDA review raised concerns about blinding, durability, and safety characterisation.

Full MDMA profile
IndicationApproximately 1 in 4 adults experience mental health disorders annually worldwide.

Equity and Ethics

Equity and ethics in psychedelic research is a vital and complex topic, addressing the need for fair access and representation in clinical trials, as well as the stewardship of traditional knowledge. The involvement of Indigenous communities, who have historically used these substances, must be safeguarded against exploitation as the field matures.

Full Equity and Ethics profile

Academic Research

18 papers
Open Accessindividual

Expert opinions on implementation of MDMA-assisted therapy in Europe: critical appraisal towards training, clinical practice, and regulation

This survey (n=68) of researchers and clinicians involved in MDMA-assisted therapy (MDMA-AT) examines opinions on clinical practices, training, and regulation. The study finds broad support for training standardization and highlights challenges in the national (European) approval process. Experts emphasize the importance of science-informed policy, active regulatory involvement, and international cooperation to integrate MDMA-AT into the European mental healthcare system, particularly for treating PTSD.

Published
August 8, 2024
Journal
European Journal of Psychotraumatology
Authors
Van Dongen, N. N. N., Zijlmans, J., Vermetten, E., Herpers, J., Maximets, N.
Open Accessmeta

Developing an Ethics and Policy Framework for Psychedelic Clinical Care: A Consensus Statement

A multidisciplinary group produced a consensus ethics and policy framework for integrating government‑approved psychedelic medicines into clinical care, articulating 20 consensus points across five core ethical domains. The statement assigns responsible actors for implementation and identifies areas for further research and policy deliberation to promote equitable, safe adoption in mainstream medicine.

Published
June 4, 2024
Journal
JAMA Network Open
Authors
McGuire, A. L., Cohen, I. G., Sisti, D., Baggott, M., Celidwen, Y., Devenot, N., Gracias, S., Grob, C. S., Harvey, I., Kious, B., Marks, M., Mithoefer, M. C., Nielson, E. M., Öngür, D., Pallas, A., Peterson, A., Schenberg, E. E., Summergrad, P., Waters, B., Williams, M. T., Yaden, D. B.
Paywallmeta

Getting in Touch with Touch: The Importance of Studying Touch in MDMA-Assisted Therapy and the Development of a New Self-Report Measure

This literature review examines the role of therapeutic touch in MDMA-assisted therapy (MDMA-AT), addressing concerns about power imbalances and ethical boundaries. It introduces the Touch Outcomes Measurement Inventory (TOMI) to assess client perceptions of touch in MDMA-AT, emphasizing the need for evidence-based and ethical guidelines in psychedelic-assisted therapy.

Published
March 1, 2024
Journal
Psychedelic Medicine
Authors
Luoma, J. B., Allen, L. R., Gold, V., Stauffer, C.
Open Accessindividual

Psychedelics-assisted psychotherapy: Experiences with the limited medical use of LSD, MDMA, and psilocybin in Switzerland

This paper summarises Switzerland’s experience with limited medical use of LSD, MDMA and psilocybin since 2014—reporting over 1,000 exemption approvals and an estimated 2,000–3,000 treatments—and provides an overview of application procedures, indications, treatment settings and phases, plus recommendations on therapist training, ethics and quality assurance for integrating psychedelics‑assisted psychotherapy into clinical practice.

Published
February 15, 2024
Journal
Die Psychotherapie
Authors
Aicher, H. D., Schmid, Y., Gasser, P.
Paywallindividual

Expert Opinion on Psychedelic-Assisted Psychotherapy for People with Psychopathological Psychotic Experiences and Psychotic Disorders

This expert consultation study (n=12) investigated the exclusion of individuals with personal or familial histories of psychopathological experiences from most psychedelic clinical trials and treatment programs. Experts in psychiatry, clinical psychology, medicine, and psychedelics were interviewed, and the findings revealed that exclusion criteria may be justified in studies with minimal psychological support. They agreed that psychedelic-assisted psychotherapy, as well as therapy with MDMA and ketamine, might be beneficial for some individuals within this group.

Published
September 19, 2023
Journal
International Journal of Mental Health and Addiction
Authors
La Torre, J. T., Mahammadli, M., Faber, S., Greenway, K. T., Williams, M. T., Abbate, V.
Open Accessmeta

MDMA-assisted psychotherapy for PTSD in adolescents: rationale, potential, risks, and considerations

This article (2023) advocates for MDMA-assisted psychotherapy (MDMA-AT) in treating adolescent PTSD, highlighting potential benefits such as reduced avoidance and enhanced therapeutic alliance. It proposes adaptations including stronger motivation reinforcement, additional emotion management techniques, and family involvement, and calls for clinical trials to assess safety and effectiveness.

Published
July 2, 2023
Journal
European Child and Adolescent Psychiatry
Authors
Kangaslampi, S., Zijlmans, J.

Clinical Trials

1 trial
RecruitingPhase NA

Evaluating the atittudes of Australian psychologists, psychiatrists and mental health researchers towards 3,4-Methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for the treatment of PTSD: A double-blind, randomised controlled trial

This double-blind, randomised controlled trial (n=200) aims to evaluate the attitudes of Australian psychologists, psychiatrists, and mental health researchers towards MDMA-assisted psychotherapy for the treatment of PTSD.

Started
February 11, 2020
Type
interventional
Blinding
single
Randomized
Yes
Registry ID
ACTRN12620001068954

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