DMT for Neuroimaging & Brain Measures

Characterizing Resting-State Brain Dynamics with Frequency-Resolved EEG Microstates: Parallel Analyses of Psilocybin Microdosing and Acute Inhaled DMT

This brain imaging secondary analysis of two studies compared resting-state EEG microstate patterns during psilocybin microdosing and acute inhaled DMT, and found that frequency-specific analysis picked up changes that broadband analysis sometimes missed. Psilocybin microdosing had subtle effects, while DMT produced broader shifts in brain activity patterns.

Published: May 8, 2026
Journal: Biorxiv
Authors: Tarailis, P., Griskova-Bulanova, I.

Open Accessindividual

Time-resolved Neural and Experience Dynamics of Medium- and High-dose N,N-Dimethyltryptamine

This repeated-measures dose-dependent study (n=19) investigates DMT's subjective and neural dynamics under naturalistic conditions. Participants received 20mg or 40mg doses of freebase DMT in a blinded, counterbalanced design, with EEG data and time-resolved subjective measures collected. The 40mg dose produced more intense visual hallucinations and emotional responses. Neural analyses revealed alpha power and permutation entropy were most associated with subjective experiences, whereas lempel-ziv complexity was less predictive, challenging prior assumptions about its role in psychedelic states.

Published: December 30, 2025
Journal: Journal of Cognitive Neuroscience
Authors: Lewis-Healey, E., Pallavicini, C., Cavanna, F., D'Amelio, T., de la Fuente, L. A., Copa, D., Muller, S., Bruno, N., Tagliazucchi, E., Bekinschtein, T.

Open Accessindividual

Inhaled N, N-dimethyltryptamine diminishes connectivity between the ventral tegmental area and the nucleus accumbens: relevance to pathologies of mesolimbic and mesocortical pathways

In a within-subject pharmacoimaging study of 11 healthy psychedelic-experienced volunteers, inhaled DMT acutely reduced connectivity between the left ventral tegmental area and the right nucleus accumbens while increasing connectivity between the nucleus accumbens and anterior cingulate cortex and between the medial prefrontal cortex and anterior cingulate. These connectivity shifts correlated with changes in volition and perception and suggest a potential therapeutic mechanism for disorders of reward processing.

Published: December 12, 2025
Journal: Scientific Reports
Authors: Lima, G., Soares, C., Teixeira, M., Pais, M., Cabral, C., Rijo, P., Castelo-Branco, M.

Open Accessindividual

A novel psychedelic 5-HT2A receptor agonist GM-2505: The pharmacokinetic, safety, and pharmacodynamic profile from a randomized trial healthy volunteer

In a randomized, placebo‑controlled ascending‑dose study in 48 healthy volunteers, single IV doses of GM‑2505 up to 20 mg were well tolerated and showed dose‑proportional pharmacokinetics (t1/2 40–50 min) with dose‑dependent neuroendocrine, neurophysiological and subjective psychedelic effects, including decreased theta/alpha and increased gamma EEG power. The duration of cardiovascular and subjective effects was intermediate between psilocybin and DMT, indicating a practical 10–15 mg IV dose range for supervised clinical use.

Published: October 16, 2025
Journal: Journal of Psychopharmacology
Authors: Marek, G. J., Makai-Bölöni, S., Umbricht, D., Christian, E. P., Winters, J., Dvorak, D., Raines, S., Hughes, Z. A., Austin, E. W., Klein, A. K., Leong, W., Krol, F. J., Van Der Graaf, A. J., Juachon, M. J., Otto, M. E., Borghans, L. G. J. M., Jacobs, G., Kruegel, A. C., Sporn, J.

Open Accessindividual

Meditation, psychedelics, and brain connectivity: A randomized controlled resting-state fMRI study of N,N-dimethyltryptamine and harmine in a meditation retreat

In a double-blind, placebo-controlled resting-state fMRI study of 40 meditation practitioners, buccal DMT–harmine increased functional connectivity within the visual network and between visual and attention/salience networks, whereas meditation with placebo produced greater network segregation. No prolonged disruption of cortical gradients was observed, indicating a return to typical brain organisation shortly after the experience and pointing to distinct neural mechanisms — and potential clinical complementarities — between meditation and psychedelic-augmented meditation.

Published: September 29, 2025
Journal: Imaging Neuroscience
Authors: Egger, K., Meling, D., Polat, F., Seifritz, E., Avram, M., Scheidegger, M.

Open Accessindividual

N,N-dimethyltryptamine effects on connectome harmonics, subjective experience and comparative psychedelic experiences

This neuroscience secondary (n=25) of two earlier studies used connectome harmonic decomposition to analyse how DMT affects brain function across the structural connectome (white matter pathways), finding that DMT reshapes the connectome harmonic repertoire and increases repertoire entropy similarly to other psychedelics (psilocybin, LSD, ketamine), and importantly demonstrating for the first time that energy spectrum differences and repertoire entropy measures correlate with subjective experience intensity in a time-resolved manner, revealing close coupling between connectome harmonics and conscious experience under psychedelics.

Published: September 12, 2025
Journal: Neuropsychopharmacology
Authors: Vohryzek, J., Luppi, A. I., Atasoy, S., Deco, G., Carhart-Harris, R. L., Timmermann, C., Kringelbach, M. L.

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Neuroimaging & Brain Measures

Academic Research

Characterizing Resting-State Brain Dynamics with Frequency-Resolved EEG Microstates: Parallel Analyses of Psilocybin Microdosing and Acute Inhaled DMT

Time-resolved Neural and Experience Dynamics of Medium- and High-dose N,N-Dimethyltryptamine

Inhaled N, N-dimethyltryptamine diminishes connectivity between the ventral tegmental area and the nucleus accumbens: relevance to pathologies of mesolimbic and mesocortical pathways

A novel psychedelic 5-HT2A receptor agonist GM-2505: The pharmacokinetic, safety, and pharmacodynamic profile from a randomized trial healthy volunteer

Meditation, psychedelics, and brain connectivity: A randomized controlled resting-state fMRI study of N,N-dimethyltryptamine and harmine in a meditation retreat

N,N-dimethyltryptamine effects on connectome harmonics, subjective experience and comparative psychedelic experiences

Clinical Trials

Direct Comparison of Altered States of Consciousness Induced by LSD, Psilocybin, and DMT in Healthy Participants (LPD)

Study of the Safety, Tolerability, Electrophysiological Effects and Efficacy of DMT in Humans (DMT-Bolus)

Investigation of Psychedelic Effects in Psychoactive Substances

Acute Analgesic Effects of DMT on Experimentally Induced Pain in Healthy Participants

Acute Dose-dependent Effects of DMT-bolus Applications in Healthy Subjects (DMT BDR-Study) (DMT BDR)

Single and Repeat Doses of DMT in Healthy Subjects

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