Trends in the Top-Cited Articles on Classic Psychedelics

This study was designed to identify trends in the top-cited classic psychedelic publications. The top 50 publications on classic psychedelics with the greatest total of number of citations and annual citation rate were identified and pooled. Unique articles (n = 77) were dichotomized by median year of publication (2010); the differential distribution of study characteristics between the “Recent Cohort” (n = 40) and “Older Cohort” (n = 37) were documented. The Recent Cohort had a greater annual citation rate (median 76.5, IQR 43.8 to 103.3) compared to the Older Cohort (median 8.8, IQR 4.2 to 17.2, p < .001). The Recent Cohort included a greater number of clinical studies (n = 27 [67.5%] vs. n = 10 [27.0%]) while the Older Cohort included more basic science and preclinical studies (n = 22 [59.5%] vs. n = 3 [7.5%], p < .001). Psilocybin was the predominant psychedelic studied in the Recent Cohort (n = 26 [40.6%] vs. n = 8 [17.4%]) while lysergic acid diethylamide (LSD) was predominantly studied in the Older Cohort (n = 26 [56.5%] vs. n = 19 [29.7%], p = .028). The Recent Cohort included more studies examining affective disorders (n = 16 [25.8%] vs. n = 1 [2.7%]) and substance use disorders (n = 6 [9.7%] vs. n = 1 [2.7%]), while the Older Cohort included a greater number of pharmacological outcomes (n = 26 [70.3%] vs. n = 11 [17.7%], p < .001). This study identified and documented trends in the top-cited classic psychedelic publications. The field is continuing to form a foundational understanding of the pharmacological effects of psychedelics and is now advancing with the identification of therapeutic uses within clinical populations.