A Gratuitous Grace: The Influence of Religious Set and Intent on the Psychedelic Experience

A majority of respondents reported characteristics typical of samples drawn from psychedelic-related web forums (predominantly White, male, and with some college education). The primary analytical finding reported was a positive association between religious set and mystical experiences during psychedelic use. Specifically, respondents who reported using psychedelics with religious intent and those who identified with a religion were more likely to score higher on the Mysticism Scale than those who did not. When controlling for covariates including type of drug taken, frequency of use, and number of people present during use, identifying with a religion remained associated with higher mysticism scores but this relationship weakened to marginal significance (p = .052). By contrast, the association between using psychedelics with religious/spiritual intent and having a mystical experience remained statistically significant after these controls (p ≤ .001). The extracted text does not provide additional numerical effect sizes, confidence intervals, or details of the statistical models used.

The researchers concluded that a person’s religious set — both identifying with a religion and taking psychedelics with religious intent — is positively associated with reporting stronger mystical experiences when using psychedelic drugs. The association for religious identification attenuated and became only marginally significant once drug type, frequency of use, and social context were controlled for, whereas religious or spiritual intent remained robustly associated with mystical experience. The authors note that the directionality of the relationship is unclear: psychedelic use may reinforce pre-existing spiritual beliefs, or people with a propensity toward spirituality may be more likely to seek religious or spiritual experiences with psychedelics. They cite prior work suggesting that first-time ayahuasca users sometimes have experiences that reinforce existing spiritual beliefs, and recommend further in-depth and qualitative research to clarify causality. The paper highlights implications for sociological and anthropological understanding of religion and for potential therapeutic or clinical applications, arguing that intent matters and may influence outcomes. The authors also point to legal restrictions on psychedelic substances in the U.S. as a barrier to fully understanding their role in contemporary Western religious practice. Finally, they emphasise harm-reduction implications: although many respondents showed awareness of safer practices, the sample was drawn from engaged members of the psychedelic community, and the authors recommend education efforts targeted at more marginal users who may not be connected to harm-reduction networks.