Alcohol Use Disorder (AUD)Substance Use Disorders (SUD)Safety & Risk ManagementLSD

Lysergic acid diethylamide (LSD) for alcoholism: meta-analysis of randomized controlled trials

This very stringent meta-analysis (including 6 trials, n=536) concludes that a single session/dose of LSD treatment has short-term (<6 months) effects on alcoholism (less misuse, more abstinence) but no positive long-term outcomes (>12 months).

Authors

  • Krebs, T. S.
  • Johansen, P. Ø.

Published

Journal of Psychopharmacology
meta Study

Abstract

Assessments of lysergic acid diethylamide (LSD) in the treatment of alcoholism have not been based on quantitative meta-analysis. Hence, we performed a meta-analysis of randomized controlled trials in order to evaluate the clinical efficacy of LSD in the treatment of alcoholism. Two reviewers independently extracted the data, pooling the effects using odds ratios (ORs) by a generic inverse variance, random effects model. We identified six eligible trials, including 536 participants. There was evidence for a beneficial effect of LSD on alcohol misuse (OR, 1.96; 95% CI, 1.36-2.84; p = 0.0003). Between-trial heterogeneity for the treatment effects was negligible (I² = 0%). Secondary outcomes, risk of bias and limitations are discussed. A single dose of LSD, in the context of various alcoholism treatment programs, is associated with a decrease in alcohol misuse.

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Research Summary of 'Lysergic acid diethylamide (LSD) for alcoholism: meta-analysis of randomized controlled trials'

Introduction

Alcohol causes substantial global harm and remains difficult to treat: alcoholism (alcohol dependence) contributes notably to mortality and disability and many patients fail to achieve recovery with existing interventions. Earlier clinical investigators reported that single, supervised doses of lysergic acid diethylamide (LSD), given alongside psychosocial treatments, produced profound subjective experiences that were claimed to reduce relapse, but these reports had not been synthesised with modern systematic review methods. Krebs and colleagues therefore set out to perform a quantitative meta-analysis of randomized controlled trials to evaluate whether LSD, administered as a single dose within alcoholism treatment programmes, affects subsequent alcohol misuse. The aim was to pool trial data to estimate efficacy, examine follow-up intervals, and assess adverse events and risk of bias across the trials.

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Study Details

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