Headache Disorders (Cluster & Migraine)Palliative & End-of-Life DistressSchizophreniaMedicinal Chemistry & Drug DevelopmentChronic PainDepressive DisordersAnxiety DisordersLSD

The pharmacology of lysergic acid diethylamide: a review

This paper (2008) extensively reviews the pharmacology and psychopharmacology of LSD.

Authors

  • Thomas Passie
  • James Halpern

Published

CNS Neuroscience and Therapeutics
meta Study

Abstract

Lysergic acid diethylamide (LSD) was synthesized in 1938 and its psychoactive effects discovered in 1943. It was used during the 1950s and 1960s as an experimental drug in psychiatric research for producing so-called “experimental psychosis” by altering neurotransmitter system and in psychotherapeutic procedures (“psycholytic” and “psychedelic” therapy). From the mid 1960s, it became an illegal drug of abuse with widespread use that continues today. With the entry of new methods of research and better study oversight, scientific interest in LSD has resumed for brain research and experimental treatments. Due to the lack of any comprehensive review since the 1950s and the widely dispersed experimental literature, the present review focuses on all aspects of the pharmacology and psychopharmacology of LSD. A thorough search of the experimental literature regarding the pharmacology of LSD was performed and the extracted results are given in this review. (Psycho-) pharmacological research on LSD was extensive and produced nearly 10,000 scientific papers. The pharmacology of LSD is complex and its mechanisms of action are still not completely understood. LSD is physiologically well tolerated and psychological reactions can be controlled in a medically supervised setting, but complications may easily result from uncontrolled use by layman. Actually there is new interest in LSD as an experimental tool for elucidating neural mechanisms of (states of) consciousness and there are recently discovered treatment options with LSD in cluster headache and with the terminally ill.

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Research Summary of 'The pharmacology of lysergic acid diethylamide: a review'

Introduction

Lysergic acid diethylamide (LSD) is a semisynthetic derivative of lysergic acid originally obtained from the rye fungus Claviceps purpurea. Albert Hofmann synthesised LSD in 1938 and discovered its psychoactive properties in 1943. During the 1950s and 1960s LSD was widely used in psychiatric research both as an experimental tool to model psychotic-like states and as an adjunct in psychotherapeutic approaches described as psycholytic or psychedelic therapy. Recreational and spiritual use expanded in the late 1960s, after which regulatory restrictions and declines in research funding sharply reduced clinical work with the drug. Passie and colleagues set out to review the pharmacology and psychopharmacology of LSD because the experimental literature is extensive, dispersed across many decades and languages, and no comprehensive review had been available since the 1950s. The review aims to collate chemical, pharmacokinetic, pharmacodynamic, toxicological, physiological, and psychiatric data from the experimental literature to provide an updated synthesis useful for researchers and clinicians interested in LSD as a research tool and potential therapeutic agent.

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References (7)

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