Safety and efficacy of lysergic acid diethylamide-assisted psychotherapy for anxiety associated with life-threatening diseases
This double-blind cross-over study (n=12) showed that LSD (200 μg, 2 sessions) in combination with psychotherapy was safe to use and trended towards a positive effect on end-of-life anxiety.
Authors
- Rick Doblin
- Berra Yazar-Klosinski
- Peter Gasser
Published
Abstract
A double-blind, randomized, active placebo-controlled pilot study was conducted to examine safety and efficacy of lysergic acid diethylamide (LSD)-assisted psychotherapy in 12 patients with anxiety associated with life-threatening diseases. Treatment included drug-free psychotherapy sessions supplemented by two LSD-assisted psychotherapy sessions 2 to 3 weeks apart. The participants received either 200 μg of LSD (n = 8) or 20 μg of LSD with an open-label crossover to 200 μg of LSD after the initial blinded treatment was unmasked (n = 4). At the 2-month follow-up, positive trends were found via the State-Trait Anxiety Inventory (STAI) in reductions in trait anxiety (p = 0.033) with an effect size of 1.1, and state anxiety was significantly reduced (p = 0.021) with an effect size of 1.2, with no acute or chronic adverse effects persisting beyond 1 day after treatment or treatment-related serious adverse events. STAI reductions were sustained for 12 months. These results indicate that when administered safely in a methodologically rigorous medically supervised psychotherapeutic setting, LSD can reduce anxiety, suggesting that larger controlled studies are warranted.
Research Summary of 'Safety and efficacy of lysergic acid diethylamide-assisted psychotherapy for anxiety associated with life-threatening diseases'
Introduction
Gasser and colleagues situate their work in the context of persistent anxiety, depression and related distress among people with life‑threatening illnesses, noting that many patients fail to obtain satisfactory emotional relief from currently available treatments. Earlier clinical research with lysergic acid diethylamide (LSD) was halted by the early 1970s, leaving uncertainty about its safety and therapeutic potential when combined with psychotherapy under contemporary research standards. The authors identify a gap in the literature for rigorously controlled studies of LSD‑assisted psychotherapy in this patient group. This study set out to evaluate the safety and efficacy of LSD‑assisted psychotherapy for anxiety associated with life‑threatening disease. Using a contemporary randomised, double‑blind, active placebo‑controlled design, the investigators tested a two‑session LSD‑assisted psychotherapy protocol embedded in preparatory and integrative drug‑free psychotherapy, with follow‑up assessments to examine short‑ and longer‑term effects on anxiety and related outcomes.
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Study Details
- Study Typeindividual
- Journal
- Compound
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- APA Citation
Gasser, P., Holstein, D., Michel, Y., Doblin, R., Yazar-Klosinski, B., Passie, T., & Brenneisen, R. (2014). Safety and efficacy of lysergic acid diethylamide-assisted psychotherapy for anxiety associated with life-threatening diseases. Journal of Nervous & Mental Disease, 202(7), 513-520. https://doi.org/10.1097/NMD.0000000000000113
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