Trial PaperAlcohol Use Disorder (AUD)Opioid Use Disorder (OUD)Tobacco/Nicotine Use Disorder (TUD)Substance Use Disorders (SUD)Safety & Risk ManagementInterpersonal Functioning & Social ConnectednessPublic Health, Prevention & Behaviour ChangePsilocybin

Psilocybin for Opioid Use Disorder in Two Adults Stabilized on Buprenorphine: A Technical Report on Study Modifications and Preliminary Findings

This safety-feasibility trial (n=2) explored the interaction between psilocybin and buprenorphine in adults with opioid use disorder (OUD). The study found that coadministration of psilocybin and buprenorphine was safely tolerated, with no serious adverse events or significant changes in opioid craving or withdrawal measures. Feasibility challenges led to modifications in the study population and eligibility criteria, emphasizing the need for improved accessibility and overall generalizability.

Authors

  • Christopher Nicholas
  • Paul Hutson

Published

Psychedelic Medicine
individual Study

Abstract

Background

Psilocybin has demonstrated promising clinical outcomes for nicotine and alcohol use disorders, yet its potential clinical utility in the treatment of opioid use disorder (OUD) remains unreported in modern literature. This technical report presents methodological considerations and preliminary data from a safety-feasibility trial examining the interaction between psilocybin and buprenorphine in two adults diagnosed with OUD.

Procedures

Two adults meeting eligibility criteria for long-term stabilization of buprenorphine/naloxone (≥6 months) enrolled and underwent two psilocybin dosing sessions in a supportive setting. Preliminary data pertaining to the safety, clinical outcomes, and subjective effects of psilocybin were collected.Main Findings: Two participants received psilocybin and completed all study visits. Feasibility considerations were identified, including limitations in provider-based recruitment strategies, participant accessibility, flexibility of the study schedule, and initial eligibility criteria. There were no serious adverse events or significant baseline changes on measures of opioid craving or withdrawal, and the subjective effects associated with psilocybin were consistent with previous studies.Principal Conclusions: Coadministration of psilocybin and buprenorphine was safely tolerated and did not demonstrate contraindicating effects vis-à-vis effectiveness of buprenorphine or the subjective effects of psilocybin. Challenges in feasibility led to modifications in the sample population and eligibility criteria and strategies to improve accessibility, minimize burden, and enhance overall generalizability.

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Research Summary of 'Psilocybin for Opioid Use Disorder in Two Adults Stabilized on Buprenorphine: A Technical Report on Study Modifications and Preliminary Findings'

Introduction

Opioid use disorder (OUD) remains a major public health problem in the United States despite established medications for OUD (MOUD) such as methadone and buprenorphine, which reduce mortality and improve retention. Previous trials of psilocybin-assisted therapy (PAT) have shown preliminary efficacy and acceptable safety for several mental health conditions and for substance use disorders such as alcohol and nicotine use disorders. However, modern clinical data on psilocybin for OUD are lacking, although earlier population-based and historical LSD work suggest potential relevance. Proposed therapeutic mechanisms for PAT that could apply to OUD include increases in psychological flexibility, mindfulness, motivation, prosociality, and experiences described as mystical or awe-related, possibly mediated by neuroplasticity and changes in predictive models of addiction-related cognition and behaviour. Nicholas and colleagues reported a technical safety–feasibility study that aimed to evaluate coadministration of psilocybin with buprenorphine in adults stabilised on buprenorphine/naloxone. The report focuses on study design decisions, logistical and safety considerations, and preliminary outcomes from the first two enrolled participants, to inform future trials and methodology for evaluating psilocybin in outpatient, community-based OUD populations.

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Study Details

References (33)

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