Depressive DisordersPTSDAnxiety DisordersSubstance Use Disorders (SUD)Medicinal Chemistry & Drug Development

Psychedelics promote structural and functional neural plasticity

This cell (in vitro) and animal (in vivo, larvae & rats) study shows the various ways (stimulation of the TrkB, mTOR, and 5-HT2A signaling pathways) through which psychedelics promote/increase plasticity in the brain.

Authors

  • Lindsay Cameron

Published

Cell Reports
individual Study

Abstract

Atrophy of neurons in the prefrontal cortex (PFC) plays a key role in the pathophysiology of depression and related disorders. The ability to promote both structural and functional plasticity in the PFC has been hypothesized to underlie the fast-acting antidepressant properties of the dissociative anesthetic ketamine. Here, we report that, like ketamine, serotonergic psychedelics are capable of robustly increasing neuritogenesis and/or spinogenesis both in vitro and in vivo. These changes in neuronal structure are accompanied by increased synapse number and function, as measured by fluorescence microscopy and electrophysiology. The structural changes induced by psychedelics appear to result from stimulation of the TrkB, mTOR, and 5-HT2A signaling pathways and could possibly explain the clinical effectiveness of these compounds. Our results underscore the therapeutic potential of psychedelics and, importantly, identify several lead scaffolds for medicinal chemistry efforts focused on developing plasticity-promoting compounds as safe, effective, and fast-acting treatments for depression and related disorders.

Available with Blossom Pro

Research Summary of 'Psychedelics promote structural and functional neural plasticity'

Introduction

Neuropsychiatric disorders such as depression, post-traumatic stress disorder (PTSD), and addiction are highly disabling and often refractory to existing antidepressant treatments, which typically require weeks to produce effects and fail in roughly one-third of patients. Converging evidence from imaging, postmortem and animal studies implicates atrophy of prefrontal cortex (PFC) neurons—manifest as dendritic retraction, loss of spines and synapses—in the pathophysiology of these disorders, and reversing such structural deficits is proposed as a therapeutic strategy. Ketamine, a dissociative anaesthetic, has renewed interest in rapid-acting antidepressant mechanisms because it promotes dendritic spine growth, synaptic protein synthesis and strengthened synaptic responses, and produces fast antidepressant and anxiolytic effects in some treatment-resistant patients. Ly and colleagues set out to test whether classical serotonergic psychedelics and related entactogens from diverse chemical classes (tryptamines, amphetamines, ergolines, and iboga alkaloids) also promote structural and functional plasticity in cortical neurons, potentially via shared downstream signalling with ketamine. The investigators introduce the term "psychoplastogen" for compounds that rapidly induce neuronal plasticity, and aim to characterise neuritogenesis, spinogenesis and synaptogenesis induced by representative psychedelics, to compare potencies with ketamine, and to probe underlying mechanisms including BDNF/TrkB, mTOR and 5-HT2A receptor involvement. The work spans in vitro primary cortical cultures, in vivo rodent experiments and invertebrate/vertebrate developmental models to assess evolutionary conservation of effects.

Expert Research Summaries

Go Pro to access AI-powered section-by-section summaries, editorial takes, and the full research toolkit.

See Pro PlansAlready have an account? Sign in

Full Text PDF

Full Paper PDF

Pro members can view the original manuscript directly in the browser.

See Pro PlansAlready have an account? Sign in
Open PDF in new tab

Study Details

References (28)

Papers cited by this study that are also in Blossom

Antidepressant effects of ketamine in depressed patients

Berman, R. M., Cappiello, A., Anand, A. et al. · Biological Psychiatry (2000)

Therapeutic mechanisms of classic hallucinogens in the treatment of addictions: from indirect evidence to testable hypotheses

Bogenschutz, M. P., Pommy, J. A. · Drug Testing and Analysis (2012)

MDMA-assisted psychotherapy using low doses in a small sample of women with chronic posttraumatic stress disorder

Bouso, J. C., Doblin, R., Farré, M. et al. · Journal of Psychoactive Drugs (2008)

Effects of N, N-Dimethyltryptamine on Rat Behaviors Relevant to Anxiety and Depression

Cameron, L. P., Benson, C. J., Dunlap, L. E. · ACS Chemical Neuroscience (2018)

The therapeutic potential of psychedelic drugs: past, present, and future

Carhart-Harris, R. L., Goodwin, G. M. · Neuropsychopharmacology (2017)

Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study

Carhart-Harris, R. L., Bolstridge, M., Rucker, J. et al. · Lancet Psychiatry (2016)

1174 cited
Antidepressive, anxiolytic, and antiaddictive effects of ayahuasca, psilocybin and lysergic acid diethylamide (LSD): a systematic review of clinical trials published in the last 25 years

Dos Santos, R. G., Osório, F. L., Crippa, J. A. et al. · Therapeutic Advances in Psychopharmacology (2016)

248 cited
Ketamine accelerates fear extinction via mTORC1 signaling

Girgenti, M. J., Ghosal, S., Lopresto, D. et al. · Neurobiology of Disease (2017)

Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance

Griffiths, R. R., Richards, W. A., Mccann, U. et al. · Journal of Psychopharmacology (2006)

Mystical-type experiences occasioned by psilocybin mediate the attribution of personal meaning and spiritual significance 14 months later

Griffiths, R. R. · Journal of Psychopharmacology (2008)

Show all 28 references
Psilocybin occasioned mystical-type experiences: immediate and persisting dose-related effects

Griffiths, R. R., Johnson, M. W., Richards, W. A. et al. · Psychopharmacology (2011)

Pilot study of psilocybin treatment for anxiety in patients with advanced-stage cancer

Grob, C. S., Danforth, A. L., Chopra, G. S. et al. · JAMA Psychiatry (2011)

Ketamine psychotherapy for heroin addiction: immediate effects and two-year follow-up

Krupitsky, E. M., Burakov, A. M., Romanova, T. N. et al. · Journal of Substance Abuse Treatment (2002)

Psychedelic Drugs in Biomedicine

Kyzar, E. J., Nichols, C. D., Gainetdinov, R. R. et al. · Trends in Pharmacological Sciences (2017)

Peak experiences and the afterglow phenomenon: when and how do therapeutic effects of hallucinogens depend on psychedelic experiences

Majic, T., Schmidt, T. T., Gallinat, J. · Journal of Clinical Psychopharmacology (2015)

Novel psychopharmacological therapies for psychiatric disorders: psilocybin and MDMA

Grob, C. S., Mithoefer, M. C., Brewerton, T. D. · Lancet Psychiatry (2016)

Rapid and Longer-Term Antidepressant Effects of Repeated Ketamine Infusions in Treatment-Resistant Major Depression

Murrough, J. W., Perez, A. M., Pillemer, S. et al. · Biological Psychiatry (2012)

Psychedelics as Medicines: An Emerging New Paradigm

Nichols, C. D., Nichols, D. E., Johnson, M. W. · Clinical Pharmacology and Therapeutics (2016)

A randomized, controlled pilot study of MDMA (±3,4-Methylenedioxymethamphetamine)- assisted psychotherapy for treatment of resistant, chronic Post-Traumatic Stress Disorder (PTSD)

Oehen, P., Traber, R., Widmer, V. et al. · Journal of Psychopharmacology (2012)

328 cited
Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report

Osório, F. L., Sanches, R. F., Macedo, L. et al. · brazilian Journal of Psychiatry (2015)

420 cited
Psychedelics in the treatment of unipolar mood disorders: a systematic review

Rucker, J., Young, A. H., Jelen, L. A. et al. · Journal of Psychopharmacology (2016)

Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression a SPECT study

Sanches, R. F., Osório, F. L., Dos Santos, R. G. et al. · Journal of Clinical Psychopharmacology (2016)

380 cited
Effects of ayahuasca on psychometric measures of anxiety, panic-like and hopelessness in Santo Daime members

Santos, R. G., Landeira-Fernandez, J., Strassman, R. J. et al. · Journal of Ethnopharmacology (2007)

The neurobiology of psychedelic drugs: implications for the treatment of mood disorders

Vollenweider, F. X., Kometer, M. · Nature Reviews Neuroscience (2010)

Crystal Structure of an LSD-Bound Human Serotonin Receptor

Wacker, D., Wang, S., Mccorvy, J. D. et al. · Cell (2017)

Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

Yang, Y., Cui, Sang, K. et al. · Nature (2018)

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

Zanos, P., Moaddel, P. J., Morris, P. J. et al. · Nature (2016)

Replication of Ketamine’s Antidepressant Efficacy in Bipolar Depression: A Randomized Controlled Add-On Trial

Zarate, C. A., Brutsche, N. E., Ibrahim, L. et al. · Biological Psychiatry (2012)

757 cited

Cited By (227)

Papers in Blossom that reference this study

Detecting neuroplastic effects induced by ketamine in healthy human subjects: A multimodal approach

Agnorelli, C., Peill, J., Sawicka, G. et al. · Journal of Cerebral Blood Flow and Metabolism (2026)

Psychedelic therapy and postpartum depression: priorities and prospects

Thuery, G., Crossen, F., Mc Loone, D. et al. · Therapeutic Advances in Psychopharmacology (2026)

Pilot study of psilocybin in patients with post-treatment lyme disease

Garcia-Romeu, A., Naudé, G. P., Rebman, A. W. et al. · Scientific Reports (2026)

Psychedelic medicine: mechanisms, evidence, and translation to practice

Jacobs, E., Zahid, Z., Hinkle, J. et al. · BMJ (2026)

Increased cortical thickness and decreased brain age among special operations veterans with blast TBI after a magnesium-ibogaine protocol

Geoly, A. D., Coetzee, J. P., Buchanan, D. M. et al. · iScience (2026)

LSD microdosing in major depressive disorder: results from an open-label trial

Daldegan-Bueno, D., Donegan, C. J., Sumner, R. L. et al. · Neuropharmacology (2026)

Psychedelics produce enduring behavioral effects and functional plasticity through mechanisms independent of structural plasticity

Kramer, H. M., Hibicke, M., Middleton, J. et al. · Neuropsychopharmacology (2025)

Zalsupindole is a Nondissociative, Nonhallucinogenic Neuroplastogen with Therapeutic Effects Comparable to Ketamine and Psychedelics

Agrawal, R., Gillie, D., Mungenast, A. et al. · ACS Chemical Neuroscience (2025)

1 cited
A randomised placebo-controlled study of the effects of lysergic acid diethylamide microdosing (15 μg) on pain perception in healthy volunteers

Cavarra, M., Hutten, N. R. P. W., Schepers, J. et al. · British Journal of Pain (2025)

Ayahuasca-inspired DMT/harmine formulation alters creative thinking dynamics during artistic creation

Suay, D., Aicher, H. D., Singer, B. et al. · Journal of Psychopharmacology (2025)

Show all 227 papers
Improved mental health outcomes and normalised spontaneous EEG activity in veterans reporting a history of traumatic brain injuries following participation in a psilocybin retreat

Blest-Hopley, G., Pasculli, G., Ruffell, S. G. D. et al. · Frontiers in Psychiatry (2025)

The psychoplastogen tabernanthalog induces neuroplasticity without proximate immediate early gene activation

Aarrestad, I. K., Cameron, L. P., Fenton, E. M. et al. · Nature Neuroscience (2025)

The effects of psilocybin therapy versus escitalopram on cognitive bias: A secondary analysis of a randomized controlled trial

Henry, J., Giribaldi, B., Nutt, D. J. et al. · European Neuropsychopharmacology (2025)

Magnesium-ibogaine therapy effects on cortical oscillations and neural complexity in veterans with traumatic brain injury

Lissemore, J. I., Chaiken, A., Keller, C. J. et al. · Nature Mental Health (2025)

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Subcutaneous RE104: A Double-Blind, Randomized, Single Ascending Dose Placebo-Controlled Study

Ludbrook, G., Bryson, N., Taylor, B. et al. · Journal of Clinical Psychopharmacology (2025)

The polypharmacology of psychedelics reveals multiple targets for potential therapeutics

Jain, M. K., Gumpper, R. H., Slocum, S. T. et al. · Neuron (2025)

Exploring the Therapeutic Effects of Psychedelics Administered to Military Veterans in Naturalistic Retreat Settings

Calnan, M., Blest-Hopley, G., Busch, C. et al. · Brain and Behavior (2025)

Safety, tolerability and subjective effects of vaporized N,N-Dimethyltryptamine: A randomized double-blind clinical trial

Wießner, I., Falchi-Carvalho, M., Laborde, S. et al. · European Neuropsychopharmacology (2025)

Safety, Pharmacokinetics, and Pharmacodynamics of a 6-h N,N-Dimethyltryptamine (DMT) Infusion in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled Trial

Zuiker, R. G. J. A., Otto, M. E., Bryan, C. S. et al. · Clinical and Translational Science (2025)

Reduced Brain Responsiveness to Emotional Stimuli With Escitalopram But Not Psilocybin Therapy for Depression

Wall, M. B., Demetriou, L., Giribaldi, B. et al. · American Journal of Psychiatry (2025)

Prediction of hallucinogen persisting perception disorder and thought disturbance symptoms following psychedelic use

Zhou, K., De Wied, D., Carhart-Harris, R. L. et al. · PNAS (2025)

Network control energy reductions under DMT relate to serotonin receptors, signal diversity, and subjective experience

Singleton, S. P., Timmermann, C., Luppi, A. I. et al. · Communications Biology (2025)

Psilocybin therapy for mood dysfunction in Parkinson's disease: an open-label pilot trial

Bradley, E. R., Sakai, K., Fernandes-Osterhold, G. et al. · Neuropsychopharmacology (2025)

10 cited
Psilocybin’s lasting action requires pyramidal cell types and 5-HT2A receptors

Shao, L-X,, Tan, D., Liao, C., Davoudian, P. A. et al. · Nature Communications (2025)

Psychedelics Align Brain Activity with Context

Stoliker, D., Novelli, L., Khajehnejad, M. et al. · Biorxiv (2025)

Single-dose psilocybin therapy for alcohol use disorder: Pharmacokinetics, feasibility, safety and efficacy in an open-label study

Fink-Jensen, A., Jensen, M. E., Stenbæk, D. S. et al. · Journal of Psychopharmacology (2025)

Effects of psychoplastogens on blood levels of brain-derived neurotrophic factor (BDNF) in humans: a systematic review and meta-analysis

Calder, A. E., Hase, A., Hasler, G. · Molecular Psychiatry (2024)

Neuroplasticity and Psychedelics: a comprehensive examination of classic and non-classic compounds in pre and clinical models

Agnorelli, C., Spriggs, M. J., Godfrey, K. et al. · Preprints (2024)

Reconsidering evidence for psychedelic-induced psychosis: an overview of reviews, a systematic review, and meta-analysis of human studies

Sabé, M., Sulstarova, A., Glangetas, A. et al. · Molecular Psychiatry (2024)

Structural neural plasticity evoked by rapid-acting antidepressant interventions

Liao, C., Dua, A. N., Wojtasiewicz, C. et al. · Nature Reviews Neuroscience (2024)

Effects of a Serotonergic Psychedelic on the Lipid Bilayer

Saha, D., Singh, A., Vaidya, V. A. et al. · ACS Chemical Neuroscience (2024)

Psilocybin-assisted neurofeedback for the improvement of executive functions: a randomized semi-naturalistic-lab feasibility study

Enriquez-Geppert, S,, Lietz, M. P., O'Higgins, F. · Philosophical Transactions of the Royal Society B (2024)

The non-hallucinogenic serotonin 1B receptor is necessary for the antidepressant-like effects of psilocybin in mice

Fleury, S., Nautiyal, K. M. · Biorxiv (2024)

Human brain changes after first psilocybin use

Lyons, T., Spriggs, M. J., Kerkelä, L. et al. · Biorxiv (2024)

Large-scale brain connectivity changes following the administration of lysergic acid diethylamide, d-amphetamine, and 3,4-methylenedioxyamphetamine

Avram, M., Fortea, L., Wollner, L. et al. · Molecular Psychiatry (2024)

12 cited
Clinically relevant acute subjective effects of psychedelics beyond mystical experience

Yaden, D. B., Goldy, S. P., Weiss, B. et al. · Nature Reviews Psychology (2024)

Distinct 5-HT receptor subtypes regulate claustrum excitability by serotonin and the psychedelic, DOI

Anderson, T. L., Keady, J. V., Songrady, J. et al. · Progress in Neurobiology (2024)

8 cited
Mind over matter: the microbial mindscapes of psychedelics and the gut-brain axis

Caspani, G., Ruffell, S. G. D., Tsang, WF. et al. · Pharmacological Research (2024)

Psilocybin desynchronizes brain networks

Nicol, G. E. · Nature (2024)

160 cited
Neural Mechanisms of Resting-State Networks and the Amygdala underlying the Cognitive and Emotional Effects of Psilocybin

Stoliker, D., Novelli, L., Vollenweider, F. X. et al. · Biological Psychiatry (2024)

Acute Effects of Hallucinogens on Functional Connectivity: Psilocybin and Salvinorin-A

Bagdasarian, F. A., Hansen, H. D., Chen, J. et al. · ACS Chemical Neuroscience (2024)

The Influence of Psilocybin on Subconscious and Conscious Emotional Learning

Casanova, A. F., Ort, A., Smallridge, J. W. et al. · iScience (2024)

Long-term ayahuasca use is associated with preserved global cognitive function and improved memory: a cross-sectional study with ritual users

Fonseca, A. M., Dos Santos, R. G., Santos, F. P. et al. · European Archives of Psychiatry and Clinical Neuroscience (2024)

Novel extended-release transdermal formulations of the psychedelic N,N-dimethyltryptamine (DMT)

Witowski, C. G., Hess, M. R., Jones, N. T. et al. · European Journal of Pharmacology (2024)

Psilocybin pulse regimen reduces cluster headache attack frequency in the blinded extension phase of a randomized controlled trial

Schindler, E. A. D., Sewell, R. A., Gottschalk, C. H. et al. · Journal of the Neurological Sciences (2024)

27 cited
A dual-receptor model of serotonergic psychedelics: therapeutic insights from simulated cortical dynamics

Juliani, A., Chelu, V., Graesser, L. et al. · Biorxiv (2024)

The potential of 5-methoxy-N,N-dimethyltryptamine in the treatment of alcohol use disorder: A first look at therapeutic mechanisms of action

Tap, S. C. · Addiction Biology (2024)

Unique Psychological Mechanisms Underlying Psilocybin Therapy Versus Escitalopram Treatment in the Treatment of Major Depressive Disorder

Weiss, B., Leor Roseman, •., Giribaldi, B. et al. · International Journal of Mental Health and Addiction (2024)

Effects of DMT on mental health outcomes in healthy volunteers

Timmermann, C., Zeifman, R. J., Erritzoe, D. et al. · Scientific Reports (2024)

29 cited
Membrane Permeation of Psychedelic Tryptamines by Dynamic Simulations

Palmisano, V. F., Agnorelli, C., Fagiolini, A. et al. · Biochemistry (2024)

Modulation of long-term potentiation following microdoses of LSD captured by thalamo-cortical modelling in a randomised, controlled trial

Murphy, R. J., Godfrey, K., Shaw, A. D. et al. · BMC Psychiatry (2024)

11 cited
CCH attack frequency reduction after psilocybin correlates with hypothalamic functional connectivity

Madsen, M. K., Petersen, A. S., Stenbæk, D. S. et al. · Headache (2024)

36 cited
Psychedelics for acquired brain injury: a review of molecular mechanisms and therapeutic potential

Allen, J., Dames, S., Foldi, C. J. et al. · Molecular Psychiatry (2024)

Psilocybin for Opioid Use Disorder in Two Adults Stabilized on Buprenorphine: A Technical Report on Study Modifications and Preliminary Findings

Nicholas, C. R., Horton, D. M., Malicki, J. et al. · Psychedelic Medicine (2023)

Greater subjective effects of a low dose of LSD in participants with depressed mood

Molla, H. M., Lee, R., Tare, I. et al. · Neuropsychopharmacology (2023)

30 cited
Beyond the 5-HT2A Receptor: Classic and Nonclassic Targets in Psychedelic Drug Action

Cameron, L. P., Benetatos, J., Lewis, V. et al. · Journal of Neuroscience (2023)

45 cited
Main targets of ibogaine and noribogaine associated with its putative anti-addictive effects: A mechanistic overview

Ona, G., Reverte, I., Rossi, G. N. et al. · Journal of Psychopharmacology (2023)

Three Decades of Research on the Development of Ibogaine Treatment of Substance Use Disorders: A Scientometric Analysis

Fernandes-Nascimento, M. H., Negrão, A. B., Viana-Ferreira, K. et al. · Journal of Psychoactive Drugs (2023)

Cellular rules underlying psychedelic control of prefrontal pyramidal neurons

Ekins, T. G., Brooks, I., Kailasa, S. et al. · Biorxiv (2023)

Back from the rabbit hole. Theoretical considerations and practical guidelines on psychedelic integration for mental health specialists

Greń, J., Tylš, F., Lasocik, M. et al. · Frontiers in Psychology (2023)

Psilocybin-assisted neurofeedback for the improvement of executive functions: a semi-naturalistic-lab feasibility study

Enriquez-Geppert, S,, Krc, J., O'Higgins, F., Lietz, M. P. · OSF Preprints (2023)

Cortical structural differences following repeated ayahuasca use hold molecular signatures

Mallaroni, P., Mason, N. L., Kloft, L. et al. · Frontiers in Neuroscience (2023)

6 cited
Mechanisms and molecular targets surrounding the potential therapeutic effects of psychedelics

Jaster, A. M., González-Maeso, J. · Molecular Psychiatry (2023)

Acute mood-elevating properties of microdosed LSD in healthy volunteers: a home-administered randomised controlled trial

Murphy, R., Sumner, R. L., Evans, W. J. et al. · Biological Psychiatry (2023)

Altered State of Consciousness and Mental Imagery as a Function of N, N-dimethyltryptamine Concentration in Ritualistic Ayahuasca Users

Ramaekers, J. G., Mallaroni, P., Kloft, L. et al. · Journal of Cognitive Neuroscience (2023)

13 cited
Three Cases of Reported Improvement in Microsmia and Anosmia Following Naturalistic Use of Psilocybin and LSD

Kovacevich, A., Weleff, J., Claytor, B. et al. · Journal of Psychoactive Drugs (2023)

5 cited
MDMA-assisted psychotherapy for PTSD: Growing evidence for memory effects mediating treatment efficacy

Sarmanlu, M., Kuypers, K. P. C., Vizeli, P. et al. · Progress in Neuro-Psychopharmacology and Biological Psychiatry (2023)

Improvement in OCD symptoms associated with serotoninergic psychedelics: a retrospective online survey

Buot, A., Pallares, C., Oganesyan, A. et al. · Scientific Reports (2023)

22 cited
Therapeutic mechanisms of psychedelics and entactogens

Heifets, B. D., Olson, D. E. · Neuropsychopharmacology (2023)

Effects of psychedelics on neurogenesis: A systematic review of pre-clinical studies

Lima da Cruz, R. V., Leão, R. N., Moulin, T. C. · Biorxiv (2023)

The potential of psychedelics for the treatment of Alzheimer's disease and related dementias

Winkelman, M. J., Szabo, A., Frecska, E. · European Neuropsychopharmacology (2023)

Must Psilocybin Always “Assist Psychotherapy”?

Goodwin, G. M., Malievskaia, E., Fonzo, G. A. et al. · American Journal of Psychiatry (2023)

Sub-acute effects of psilocybin on EEG correlates of neural plasticity in major depression: Relationship to symptoms

Skosnik, P. D., Sloshower, J., Safi-Aghdam, H. et al. · Journal of Psychopharmacology (2023)

Learned Helplessness As a Potential Transdiagnostic Therapeutic Mechanism of Classic Psychedelics

Tiwari, P., Sayali, C., Doss, M. K. et al. · Psychedelic Medicine (2023)

Psychedelics reopen the social reward learning critical period

Nardou, R., Sawyer, E., Song, Y. J. et al. · Nature (2023)

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB

Moliner, R., Girych, M., Brunello, C. A. et al. · Nature Neuroscience (2023)

Acute effects of intravenous DMT in a randomized placebo-controlled study in healthy participants

Vogt, S. B., Ley, L., Erne, L. et al. · Translational Psychiatry (2023)

64 cited
Self-reported effects of classic psychedelics on stuttering

Gold, N. D., Goldway, N., Gerlach-Houck, H. et al. · Biorxiv (2023)

Human brain effects of DMT assessed via EEG-fMRI

Timmermann, C., Roseman, L., Haridas, S. et al. · PNAS (2023)

158 cited
A non-hallucinogenic LSD analog with therapeutic potential for mood disorders

Lewis, V., Bonniwell, E. M., Lanham, J. K. et al. · Cell Reports (2023)

102 cited
Canalization and plasticity in psychopathology

Carhart-Harris, R. L., Chandaria, S., Erritzoe, D. E. et al. · Neuropharmacology (2023)

The classic psychedelic DOI induces a persistent desynchronized state in medial prefrontal cortex

Olson, R., Bartlett, L., Sonneborn, A. et al. · Biorxiv (2023)

A neurophenomenological approach to non-ordinary states of consciousness: hypnosis, meditation, and psychedelics

Timmermann, C., Vollenweider, F. X. · Trends in Cognitive Sciences (2023)

Psychotherapeutic and neurobiological processes associated with ayahuasca: A proposed model and implications for therapeutic use

Perkins, D., Ruffell, S. G. D., day, K. et al. · Frontiers in Neuroscience (2023)

Optimizing outcomes in psilocybin therapy: Considerations in participant evaluation and preparation

Modlin, N. L., Miller, T. M., Rucker, J. J. et al. · Journal of Affective Disorders (2023)

5-HT2ARs Mediate Therapeutic Behavioral Effects of Psychedelic Tryptamines

Cameron, L. P., Patel, S. D., Vargas, M. V. et al. · ACS Chemical Neuroscience (2023)

86 cited
Beliefs and Perceived Barriers Regarding Psychedelic-assisted Therapy in a Pilot Study of Service Members and Veterans With a History of Traumatic Brain Injury

Gray, J. C., Murphy, M., Carter, S. E. et al. · Military Medicine (2022)

8 cited
Psychedelic Identity Shift: A Critical Approach to Set And Setting

Devenot, N., Seale-Feldman, A., Smith, E. et al. · Kennedy Institute of Ethics Journal (2022)

28 cited
Psychedelic-Assisted Therapy for People with Eating Disorders

Gukasyan, N., Schreyer, C. C., Griffiths, R. R. et al. · Current Psychiatry Reports (2022)

More than meets the eye: The role of sensory dimensions in psychedelic brain dynamics, experience, and therapeutics

Aqil, M., Roseman, L. · Neuropharmacology (2022)

Ketanserin reverses the acute response to LSD in a randomized, double-blind, placebo-controlled, crossover study in healthy subjects

Becker, A. M., Klaiber, A., Holze, F. et al. · International Journal of Neuropsychopharmacology (2022)

73 cited
Changes in mental health, wellbeing and personality following ayahuasca consumption: Results of a naturalistic longitudinal study

Perkins, D., Pagni, B. A., Sarris, J. et al. · Frontiers in Pharmacology (2022)

40 cited
The neural basis of psychedelic action

Kwan, A. C., Olson, D. E., Preller, K. H. et al. · Nature Medicine (2022)

Therapeutic (Sub)stance: Current practice and therapeutic conduct in preparatory sessions in substance-assisted psychotherapy-A systematized review

Thal, S. B., Wieberneit, M., Sharbanee, J. M. et al. · Journal of Psychopharmacology (2022)

Nootropic effects of LSD: Behavioral, molecular and computational evidence

Ornelas, I. M., Cini, F. A., Wießner, I. et al. · Experimental Neurology (2022)

25 cited
Towards an understanding of psychedelic-induced neuroplasticity

Calder, A. E., Hasler, G. · Neuropsychopharmacology (2022)

Self-Entropic Broadening Theory: Toward a New Understanding of Self and Behavior Change Informed by Psychedelics and Psychosis

Dourron, H. M., Strauss, C., Hendricks, P. S. · Pharmacological Reviews (2022)

A long trip into the universe: Psychedelics and space travel

Lerer, L. B., Varia, J. · Frontiers in Space Travel (2022)

2 cited
Neural Mechanisms and Psychology of Psychedelic Ego Dissolution

Stoliker, D., Egan, G. F., Friston, K. J. et al. · Pharmacological Reviews (2022)

Macrodosing to microdosing with psychedelics: Clinical, social, and cultural perspectives

Kaypak, A. C., Raz, A. · Transcultural Psychiatry (2022)

Acute and long-term effects of psilocybin on energy balance and feeding behavior in mice

Fadahunsi, N., Lund, J., Breum, A. W. et al. · Translational Psychiatry (2022)

41 cited
Pharmacological, Neural, and Psychological Mechanisms underlying Psychedelics: A Critical Review

van Elk, M., Yaden, D. B. · Neuroscience and Biobehavioral Reviews (2022)

Analgesic potential of macrodoses and microdoses of classical psychedelics in chronic pain sufferers: a population survey

Bonnelle, V., Cavarra, M., Kryskow, P. et al. · British Journal of Pain (2022)

21 cited
Effect of Psilocybin and Ketamine on Brain Neurotransmitters, Glutamate Receptors, DNA and Rat Behavior

Wojtas, A., Bysiek, A., Wawrzczak-Bargiela, A. et al. · International Journal of Molecular Sciences (2022)

79 cited
Significance of mammalian N, N-dimethyltryptamine (DMT): A 60-year-old debate

Jiménez, J. H., Bouso, J. C. · Journal of Psychopharmacology (2022)

Interest in receiving psychedelic-assisted therapy among marginalized women: Implications and findings from a community-based study in Canada

Argento, E., Goldenberg, S., Deering, K. et al. · Drug and Alcohol Dependence (2022)

4 cited
Postpartum depression: A role for psychedelics?

Jairaj, C., Rucker, J. · Journal of Psychopharmacology (2022)

Differences in personality, cognitive abilities, illicit drug use, and white matter structural integrity between hallucinogen users and matched controls

Aharon-Almagor, A., Barrett, F. S. · Research Square (2022)

A Single Belief-Changing Psychedelic Experience Is Associated With Increased Attribution of Consciousness to Living and Non-living Entities

Nayak, S., Griffiths, R. R. · Frontiers in Psychology (2022)

37 cited
Metabolomics and integrated network analysis reveal roles of endocannabinoids and large neutral amino acid balance in the ayahuasca experience

Madrid-Gambin, F., Gomez-Gomez, A., Busquets-Garcia, A. et al. · Biomedicine & Pharmacotherapy (2022)

Towards psychedelic apprenticeship: Developing a gentle touch for the mediation and validation of psychedelic-induced insights and revelations

Timmermann, C., Watts, R., Dupuis, D. · Transcultural Psychiatry (2022)

95 cited
Repeated lysergic acid diethylamide (LSD) reverses stress-induced anxiety-like behavior, cortical synaptogenesis deficits and serotonergic neurotransmission decline

De Gregorio, D., Inserra, A., Enns, J. P. et al. · Neuropsychopharmacology (2022)

Psilocybin Combines Rapid Synaptogenic And Anti-Inflammatory Effects In Vitro

Smedfors, G., Glotfelty, E., Papatziamos, C. et al. · Research Square (2022)

Beating Pain with Psychedelics: Matter over Mind?

Elman, I., Borsook, D., Pustilink, A. · Neuroscience and Biobehavioral Reviews (2022)

Direct comparison of the acute effects of lysergic acid diethylamide and psilocybin in a double-blind placebo-controlled study in healthy subjects

Holze, F., Ley, L., Müller, F. et al. · Neuropsychopharmacology (2022)

169 cited
The clinical pharmacology and potential therapeutic applications of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT)

Reckweg, J., Uthaug, M. V., Szabo, A. et al. · Journal of Neurochemistry (2022)

Psychedelic use is associated with reduced daily opioid use among people who use illicit drugs in a Canadian setting

Argento, E., Socias, M. E., Hayashi, K. et al. · International Journal of Drug Policy (2022)

Evaluating the Potential Use of Serotonergic Psychedelics in Autism Spectrum Disorder

Markopoulos, A., Inserra, A., De Gregorio, D. et al. · Frontiers in Pharmacology (2022)

30 cited
Classic Psychedelic Drugs: Update on Biological Mechanisms

Vollenweider, F. X., Smallridge, J. W. · Pharmacopsychiatry (2022)

71 cited
Administration of N,N-dimethyltryptamine (DMT) in psychedelic therapeutics and research and the study of endogenous DMT

Barker, S. A. · Psychopharmacology (2022)

43 cited
Biochemical Mechanisms Underlying Psychedelic-Induced Neuroplasticity

Olson, D. E. · Biochemistry (2022)

95 cited
MDMA/ecstasy use and psilocybin use are associated with lowered odds of psychological distress and suicidal thoughts in a sample of US adults

Jones, G. M., Nock, M. K. · Journal of Psychopharmacology (2022)

Psilocybin microdosing does not affect emotion-related symptoms and processing: A preregistered field and lab-based study

Marschall, J., Fejer, G., Lempe, P. et al. · Journal of Psychopharmacology (2021)

Psychedelic Therapy's Transdiagnostic Effects: A Research Domain Criteria (RDoC) Perspective

Dursun, S. M., Kelly, J. R., Gillan, C. M. et al. · Frontiers in Psychiatry (2021)

Psychedelic-Assisted Therapy for Substance Use Disorders and Potential Mechanisms of Action

Rieser, N. M., Herdener, M. ;., Preller, K. H. · Current Topics in Behavioral Neurosciences (2021)

A Spectrum of Selves Reinforced in Multilevel Coherence: A Contextual Behavioural Response to the Challenges of Psychedelic-Assisted Therapy Development

Whitfield, H. J. · Frontiers in Psychiatry (2021)

Psychedelic-Inspired Approaches for Treating Neurodegenerative Disorders

Olson, D. E. · Journal of Neurochemistry (2021)

Psilocybin, a Naturally Occurring Indoleamine Compound, Could Be Useful to Prevent Suicidal Behaviors

Strumila, R., Guillaume, S. · Pharmaceuticals (2021)

Acute effects of psilocybin after escitalopram or placebo pretreatment in a randomized, double-blind, placebo-controlled, cross-over study in healthy subjects

Becker, A. M., Holze, F., Grandinett, T. et al. · Clinical Pharmacology and Therapeutics (2021)

Psilocybin therapy increases cognitive and neural flexibility in patients with major depressive disorder

Doss, M. K., Považan, M., Rosenberg, M. D. et al. · Translational Psychiatry (2021)

249 cited
Psychedelics as Novel Therapeutics in Alzheimer’s Disease: Rationale and Potential Mechanisms

Garcia-Romeu, A., Darcy, S., Jackson, H. et al. · Current Topics in Behavioral Neurosciences (2021)

From Psychiatry to Neurology: Psychedelics as Prospective Therapeutics for Neurodegenerative Disorders

Nichols, C. D., Wiatr, K., Figiel, M. et al. · Journal of Neurochemistry (2021)

63 cited
Communalistic use of psychoactive plants as a bridge between traditional healing practices and Western medicine: A new path for the Global Mental Health movement

Ona, G., Berrada, A., Bouso, J. C. · Transcultural Psychiatry (2021)

Serotonergic Psychedelics in Neural Plasticity

Torregrossa, M. M., Lu, J., Lukasiewicz, K. et al. · Frontiers in Molecular Neuroscience (2021)

Prolonged epigenomic and synaptic plasticity alterations following single exposure to a psychedelic in mice

De La, M., Revenga, F., Zhu, B. et al. · Cell Reports (2021)

167 cited
Psychedelics, sociality, and human evolution

Rodríguez Arce, J. M., Winkelman, M. J. · Frontiers in Psychology (2021)

Psychedelic mushrooms in the USA: Knowledge, patterns of use and association with health outcomes

Matzopoulos, R., Morlock, A., Morlock, R. et al. · MedRvix (2021)

Critical Period Plasticity as a Framework for Psychedelic-Assisted Psychotherapy

Yehuda, R., Lepow, L., Morishita, H. · Frontiers in Neuroscience (2021)

Neuropsychological Functioning in Users of Serotonergic Psychedelics - A Systematic Review and Meta-Analysis

Basedow, L. A., Riemer, T. G., Reiche, S. et al. · Frontiers in Pharmacology (2021)

Improving cognitive functioning in major depressive disorder with psychedelics: a dimensional approach

Kuiperes, Z., Schreiber, R. · Neurobiology of Learning and Memory (2021)

Cancer Healthcare Workers' Perceptions toward Psychedelic-Assisted Therapy: A Preliminary Investigation

Reynolds, L. M, Stack, A., Akroyd, A., Sundram, F. et al. · International Journal of Environmental Research and Public Health (2021)

22 cited
Psychedelics for Brain Injury: A Mini-Review

Khan, S. I., Carter, G. T., Aggarwal, S. K. et al. · Frontiers in Neuroscience (2021)

Associations between ayahuasca consumption in naturalistic settings and current alcohol and drug use: Results of a large international cross-sectional survey

Perkins, D., Opaleye, E. S., Simonová, H. et al. · Drug and Alcohol Review (2021)

Does psychedelic therapy have a transdiagnostic action and prophylactic potential?

Kočárová, C., Horacek, J., Carhart-Harris, R. L. · Frontiers in Psychiatry (2021)

73 cited
Role of the 5-HT2A receptor in acute effects of LSD on empathy and circulating oxytocin

Holze, F., Avedisian, I., Varghese, N. et al. · Frontiers in Pharmacology (2021)

Naturalistic Entheogenics: Précis of Philosophy of Psychedelics

Letheby, C. · Psyarxiv (2021)

2 cited
Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo

Shao, L-X,, Liao, C., Gregg, I. et al. · Neuron (2021)

Psychedelics alter metaphysical beliefs

Timmermann, C., Kettner, H., Letheby, C. et al. · Scientific Reports (2021)

Psilocybin as a Novel Pharmacotherapy for Treatment-Refractory Anorexia Nervosa

Rodan, S., Aouad, P., McGregor, I. S. et al. · OBM Neurobiology (2021)

LSD induces increased signalling entropy in rats' prefrontal cortex

Savino, A., Nichols, C. D. · Biorxiv (2021)

Cross-sectional associations between lifetime use of psychedelic drugs and psychometric measures during the COVID-19 confinement: A transcultural study

Bouso, J. C., Révész, D., Ona, G. et al. · Frontiers in Psychiatry (2021)

26 cited
Psychedelic perceptions: mental health service user attitudes to psilocybin therapy

Corrigan, K., Haran, M., Mccandliss, C. et al. · Irish Journal of Medical Science (2021)

Psilocybin and MDMA for the treatment of trauma-related psychopathology

Bird, C. I. V., Modlin, N. L., Rucker, J. · International Review of Psychiatry (2021)

Catalysts for change: the cellular neurobiology of psychedelics

Bement, W., Banks, M. I., Zahid, Z. et al. · Molecular Biology of the Cell (2021)

31 cited
Psychedelics and health behaviour change

Teixeira, P. J., Johnson, M. W., Timmermann, C. et al. · Journal of Psychopharmacology (2021)

An analog of psychedelics restores functional neural circuits disrupted by unpredictable stress

Lu, J., Tjia, M., Mullen, B. et al. · Molecular Psychiatry (2021)

Psychedelic-inspired drug discovery using an engineered biosensor

Dong, C., Ly, C., Dunlap, L. E. et al. · Cell (2021)

Can pragmatic research, real-world data and digital technologies aid the development of psychedelic medicine?

Carhart-Harris, R. L., Wagner, A. C., Agrawal, M. et al. · Journal of Psychopharmacology (2021)

40 cited
Effects of Ayahuasca on the Recognition of Facial Expressions of Emotions in Naive Healthy Volunteers: A Pilot, Proof-of-Concept, Randomized Controlled Trial

Rocha, J. M., Rossi, G. N., de Lima Osório, F. et al. · Journal of Clinical Psychopharmacology (2021)

37 cited
Trial of Psilocybin versus Escitalopram for Depression

Carhart-Harris, R. L., Giribaldi, B., Watts, R. et al. · New England Journal of Medicine (2021)

927 cited
Harnessing psilocybin: antidepressant-like behavioral and synaptic actions of psilocybin are independent of 5-HT2R activation in mice

Hesselgrave, N., Troppoli, T. A., Wulff, A. B. et al. · PNAS (2021)

Spontaneous and deliberate creative cognition during and after psilocybin exposure

Mason, N. L., Kuypers, K. P. C., Reckweg, J. T. et al. · Translational Psychiatry (2021)

86 cited
A Dendrite-Focused Framework for Understanding the Actions of Ketamine and Psychedelics

Savalia, N., Shao, L-X,, Kwan, A. C. · Trends in Neuroscience (2021)

98 cited
A qualitative and quantitative account of patient’s experiences of ketamine and its antidepressant properties

Sumner, R. L., Chacko, E., Mcmillan, R. et al. · Journal of Psychopharmacology (2021)

51 cited
The Promise of Psychedelic Science

Olson, D. E. · ACS Pharmacology and Translational Science (2021)

Hallucinogenic/psychedelic 5HT2A receptor agonists as rapid antidepressant therapeutics: Evidence and mechanisms of action

Dos Santos, R. G., Hallak, J. E., Baker, G. et al. · Journal of Psychopharmacology (2021)

Acute and Sustained Reductions in Loss of Meaning and Suicidal Ideation Following Psilocybin-Assisted Psychotherapy for Psychiatric and Existential Distress in Life-Threatening Cancer

Ross, E., Agin-Liebes, G. I., Zeifman, R. J. et al. · ACS Pharmacology and Translational Science (2021)

94 cited
On the Relationship between Classic Psychedelics and Suicidality: A Systematic Review

Zeifman, R. J., Singhal, N., Breslow, L. et al. · ACS Pharmacology and Translational Science (2021)

The DMT and Psilocin Treatment Changes CD11b+ Activated Microglia Immunological Phenotype

Kozłowska, U., Klimczak, A., Wiatr, K. et al. · Biorxiv (2021)

Psilocin acutely disrupts sleep and affects local but not global sleep homeostasis in laboratory mice

Thomas, C. W., Blanco-Duque, C., Breant, B. et al. · Translational Psychiatry (2021)

Anti-inflammatory activity of ayahuasca and its implications for the treatment of neurological and psychiatric diseases

da Silva, M. G., Daros, G. C., de Bitencourt, R. M. · Behavioural Brain Research (2021)

15 cited
Positive expectations predict improved mental-health outcomes linked to psychedelic microdosing

Kaertner, L. S., Steinborn, M. B., Kettner, H. et al. · Scientific Reports (2021)

112 cited
Classic serotonergic psychedelics for mood and depressive symptoms: a meta-analysis of mood disorder patients and healthy participants

Galvão-Coelho, N. L., Marx, W., Sinclair, J. et al. · Psychopharmacology (2021)

Psychedelic Medicines in Major Depression: Progress and Future Challenges

Bouso, J. C., Ona, G., Dos Santos, R. G. et al. · Advances in Experimental Medicine and Biology (2021)

The Subjective Effects of Psychedelics Are Necessary for Their Enduring Therapeutic Effects

Yaden, D. B., Griffiths, R. R. · ACS Pharmacology and Translational Science (2020)

The Subjective Effects of Psychedelics May Not Be Necessary for Their Enduring Therapeutic Effects

Olson, D. E. · ACS Pharmacology and Translational Science (2020)

A non-hallucinogenic psychedelic analogue with therapeutic potential

Cameron, L. P., Tombari, R. J., Lu, J. et al. · Nature (2020)

70 cited
Psilocybin-Assisted Group Therapy and Attachment: Observed Reduction in Attachment Anxiety and Influences of Attachment Insecurity on the Psilocybin Experience

Stauffer, C., Anderson, B. T., Ortigo, K. M. et al. · ACS Pharmacology and Translational Science (2020)

51 cited
The History of Psychedelics in Psychiatry

Nichols, D. E., Walter, H. · Pharmacopsychiatry (2020)

The Effects of Daytime Psilocybin Administration on Sleep: Implications for Antidepressant Action

Dudysová, D., Janků, K., Šmotek, M. et al. · Frontiers in Pharmacology (2020)

25 cited
Ketamine and Serotonergic Psychedelics: Common Mechanisms Underlying the Effects of Rapid-Acting Antidepressants

Kadriu, B., Greenwald, M., Ba et al. · International Journal of Neuropsychopharmacology (2020)

Pivotal Mental States

Brouwer, A., Carhart-Harris, R. L. · Journal of Psychopharmacology (2020)

Acute dose-dependent effects of lysergic acid diethylamide in a double-blind placebo-controlled study in healthy subjects

Holze, F., Vizeli, P., Ley, L. et al. · Neuropsychopharmacology (2020)

192 cited
Psychedelic drugs: neurobiology and potential for treatment of psychiatric disorders

Vollenweider, F. X., Preller, K. H. · Nature Reviews Neuroscience (2020)

Transient Stimulation with Psychoplastogens Is Sufficient to Initiate Neuronal Growth

Greb, A. C., Vargas, M. V., Duim, W. C. et al. · ACS Pharmacology and Translational Science (2020)

Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers

Hutten, N. R. P. W., Mason, N. L., Dolder, P. C. et al. · ACS Pharmacology and Translational Science (2020)

Psychedelic science in post-COVID-19 psychiatry

Kelly, J. R., Crockett, M. T., Alexander, L. et al. · Irish Journal of Psychological Medicine (2020)

Psychedelics and virtual reality: parallels and applications

Aday, J. S., Davoli, C. C., Bloesch, E. K. · Therapeutic Advances in Psychopharmacology (2020)

A potential role for psilocybin in the treatment of obsessive-compulsive disorder

Jacobs, E. · Journal of Psychedelic Studies (2020)

Me, myself, bye: regional alterations in glutamate and the experience of ego dissolution with psilocybin

Mason, N. L., Kuypers, K. P. C., Reckweg, J. et al. · Neuropsychopharmacology (2020)

Psilocybin and LSD Have No Long-Lasting Effects in an Animal Model of Alcohol Relapse

Meinhardt, M. W., Güngör, C., Skorodumov, I. et al. · Neuropsychopharmacology (2020)

Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species

Halberstadt, A. L., Chatha, M., Klein, A. K. et al. · Neuropharmacology (2020)

210 cited
A Single Administration of the Atypical Psychedelic Ibogaine or Its Metabolite Noribogaine Induces an Antidepressant-Like Effect in Rats

Rodríguez, P., Urbanavicius, J., Prieto, J. P. et al. · ACS Chemical Neuroscience (2020)

Psychedelic Psychiatry’s Brave New World

Nutt, D. J., Erritzoe, D., Carhart-Harris, R. L. · Cell (2020)

A review of emerging therapeutic potential of psychedelic drugs in the treatment of psychiatric illnesses

Chi, T., Gold, J. A. · Journal of the Neurological Sciences (2020)

73 cited
Depression, Mindfulness, and Psilocybin: Possible Complementary Effects of Mindfulness Meditation and Psilocybin in the Treatment of Depression. A Review

Heuschkel, K., Kuypers, K. P. C. · Frontiers in Psychiatry (2020)

63 cited
Dissolving the self: Active inference, psychedelics, and ego-dissolution

Deane, G. · Philosophy and the Mind Sciences (2020)

Long-term effects of psychedelic drugs: A systematic review

Aday, J. S., Mitzkovitz, C. M., Bloesch, E. K. et al. · Neuroscience and Biobehavioral Reviews (2020)

Reviewing the potential of psychedelics for the treatment of PTSD

Krediet, E., Bostoen, T., Breeksema, J. J. et al. · International Journal of Neuropsychopharmacology (2020)

Natural Psychoplastogens As Antidepressant Agents

Benko, J., Vranková, S. · Molecules (2020)

Emotions and brain function are altered up to one month after a single high dose of psilocybin

Barrett, F. S., Doss, M. K., Sepeda, N. D. et al. · Scientific Reports (2020)

Acute effects of psilocybin on glutamate concentration levels, functional connectivity and subjective state

Mason, N. L., Feilding, A., Ramaekers, J. G. · European Neuropsychopharmacology (2020)

Persisting Reductions in Cannabis, Opioid, and Stimulant Misuse After Naturalistic Psychedelic Use: An Online Survey

Garcia-Romeu, A., Davis, A. K., Griffiths, R. R. et al. · Frontiers in Psychiatry (2020)

121 cited
Long-term follow-up of psilocybin-assisted psychotherapy for psychiatric and existential distress in patients with life-threatening cancer

Agin-Liebes, G. I., Malone, T., Yalch, M. M. et al. · Journal of Psychopharmacology (2020)

292 cited
Psilocybin-assisted therapy of major depressive disorder using Acceptance and Commitment Therapy as a therapeutic frame

Sloshower, J., Guss, J., Krause, R. et al. · Journal of Contextual Behavioral Science (2020)

Therapeutic use of serotoninergic hallucinogens: A review of the evidence and of the biological and psychological mechanisms

Dos Santos, R. G., Hallak, J. E. · Neuroscience and Biobehavioral Reviews (2020)

The Impact of Ayahuasca on Suicidality: Results From a Randomized Controlled Trial.

Araújo, D. B., Zeifman, R. J., Palhano-Fontes, F. et al. · Frontiers in Pharmacology (2019)

96 cited
Distinct acute effects of LSD, MDMA, and D-amphetamine in healthy subjects.

Holze, F., Vizeli, P., Müller, F. et al. · Neuropsychopharmacology (2019)

214 cited
Acute Subjective and Behavioral Effects of Microdoses of Lysergic Acid Diethylamide in Healthy Human Volunteers

Bershad, A. K., Schepers, S. T., Bremmer, M. P. et al. · Biological Psychiatry (2019)

Characterization and prediction of acute and sustained response to psychedelic psilocybin in a mindfulness group retreat

Smigielski, L., Kometer, M., Scheidegger, M. et al. · Scientific Reports (2019)

126 cited
Breakthrough for trauma treatment: safety and efficacy of MDMA-assisted psychotherapy compared to paroxetine and sertraline

Feduccia, A. A., Jerome, L., Yazar-Klosinski, B. et al. · Frontiers in Psychiatry (2019)

Psilocybin-assisted mindfulness training modulates self-consciousness and brain default mode network connectivity with lasting effects

Smigielski, L., Scheidegger, M., Kometer, M. et al. · NeuroImage (2019)

REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics

Carhart-Harris, R. L., Friston, K. J. · Pharmacological Reviews (2019)

Modulation of Serum Brain-Derived Neurotrophic Factor by a Single Dose of Ayahuasca: Observation From a Randomized Controlled Trial

Galvão-Coelho, N. L., de Almeida, R. N., de Menezes Galvão, A. C. et al. · Frontiers in Psychology (2019)

Psychedelic drugs-a new era in psychiatry?

Nutt, D. J. · Dialogues in Clinical Neuroscience (2019)

Psychedelics as a treatment for disorders of consciousness

Scott, G., Carhart-Harris, R. L. · Neuroscience of Consciousness (2019)

Psychedelic medicine: The biology underlying the persisting psychedelic effects

Kuypers, K. P. C. · Medical Hypotheses (2019)

Ibogaine Administration Modifies GDNF and BDNF Expression in Brain Regions Involved in Mesocorticolimbic and Nigral Dopaminergic Circuits.

Lason, W., Carnicella, S., Mash, D. C. et al. · Frontiers in Pharmacology (2019)

Chronic, Intermittent Microdoses of the Psychedelic N, N-Dimethyltryptamine (DMT) Produce Positive Effects on Mood and Anxiety in Rodents

Cameron, L. P., Benson, C. J., Defelice, B. C. et al. · ACS Chemical Neuroscience (2019)

Long-lasting analgesic effect of the psychedelic drug changa: A case report

Ona, G., Troncoso, S. · Journal of Psychedelic Studies (2019)

How do psychedelics work?

Carhart-Harris, R. L. · Current Opinion in Psychiatry (2019)

An exploratory study of experiences with conventional eating disorder treatment and ceremonial ayahuasca for the healing of eating disorders

Renelli, M., Fletcher, J., Tupper, K. W. et al. · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity (2018)

68 cited
Psychoplastogens: A Promising Class of Plasticity-Promoting Neurotherapeutics

Olson, J. A. · Neuroscience Insights (2018)

Efficacy, tolerability, and safety of serotonergic psychedelics for the management of mood, anxiety, and substance-use disorders: a systematic review of systematic reviews

Dos Santos, R. G., Bouso, J. C., Hallak, J. E. · Expert Review of Clinical Pharmacology (2018)

191 cited
Dark Classics in Chemical Neuroscience: N, N-Dimethyltryptamine (DMT)

Cameron, L. P. · ACS Chemical Neuroscience (2018)

Dark Classics in Chemical Neuroscience: 3,4-Methylenedioxymethamphetamine

Dunlap, L. E., Andrews, A. M. · ACS Chemical Neuroscience (2018)

A case report SPECT study and theoretical rationale for the sequential administration of ibogaine and 5-MeO-DMT in the treatment of alcohol use disorder

Barsuglia, J. P., Polanco, M., Palmer, R. et al. · Progress in Brain Research (2018)

Your Personal Research Library

Go Pro to save papers, add notes, rate studies, and organize your research into custom shelves.

See Pro PlansSign in